Structure of PDB 7o81 Chain Bj Binding Site BS02

Receptor Information

>7o81 Chain Bj (length=86) Species: 9986 (Oryctolagus cuniculus)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

Ligand information

>7o81 Chain B8 (length=156)

cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcu

.........................................<<<<<<<<<
....>>>>.....<.<<<......>>.............>>>..>...>>
>....<<....>><<<<<<<<<.....>>>>>>>>>..............
......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7o81 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): R20 R21 C22 G23 Y39 K42 N57 G62 R63 M64 R65 H66 L67 K68 Y71 R72 F74 H76 R79 G81 T82 P84 K85 K87
• Binding residue (residue number reindexed from 1): R19 R20 C21 G22 Y38 K41 N56 G61 R62 M63 R64 H65 L66 K67 Y70 R71 F73 H75 R78 G80 T81 P83 K84 K86

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7o81, PDBe:7o81, PDBj:7o81
• PDBsum: 7o81
• PubMed: 34029205
• UniProt: U3KPD5|RL37_RABIT Large ribosomal subunit protein eL37 (Gene Name=RPL37)