Structure of PDB 8ova Chain Bh Binding Site BS02

Receptor Information
>8ova Chain Bh (length=156) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAEARKSRDDRRWKRVLAKMDPEKRKKYHGVGNTAEHSRVRGCTRASLFK
RTGRKPDNIVMEASIHLSKLLKKRTFHKRAPIAIKRIRSFVGKLMKTKDN
RIDASLNTFIWHKGVKGVPGRVRVRVERKSETRKHFYTVISHIPVPSFKN
LTTKVI
Ligand information
>8ova Chain BB (length=1119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguaugucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacuuacguugcuucacu
uaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcg
ccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauu
uccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaag
aacaggaaauaugaacaaaucauaccagaggugucagaauaauuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagg
guuggauuguucacccacugacagggaacgugagcuggguuuagaccguc
gugagacagguugguuuuacccuacuuggcuggagauugcgaguaaaaga
uuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguugg
guggcaugugcuuggcgcu
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>.
..<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>
>>...<.<..<...>..>>....................<<<.<..>.>>
>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<
<.......>>>>>..>>.<<<....>>>.>>.........<<<<<.....
.........<<<<.......>>>>.>>>>>..........>>>>..>>>>
>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>
>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....>>..>>>.>>>>>>>...................
....<<<<.....>>>>...<<<...........>>>..........<..
<.<.......>.>.>....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		R33 W38 K39 R40 K44 Y53 V56 N58 R66 G67 K98 K103 K110
Binding residue
(residue number reindexed from 1)		R8 W13 K14 R15 K19 Y28 V31 N33 R41 G42 K73 K78 K85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ38DH8

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