Structure of PDB 8ove Chain Bf Binding Site BS02

Receptor Information
>8ove Chain Bf (length=400) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRREERL
Ligand information
>8ove Chain BB (length=1109) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caacugcagaccguacucaucaccgcaucagguccccaagcaucgaaugc
ucugguacauagagaaagguacacucagggaagucggcaaaauagaugcg
uaaguucgcaagaagcauuggcucugagggcaauugccaacucagaacug
cuuacggcggggaauccaacuguauaauuaaaacauagguuugugaugca
uccaagugguguaugucgcaaacugauuucugcccagugcucugaauguc
aacgugacgagauucaccgacgcgcggguaaacggcgggaguaacuauga
cucucuuaagguagccaaaugccucgucuuccaauuagagacgcgcauga
auggauuaaugagauucccucugucccgaguuacuaucuagcgaaacgac
agucaagggaacggacuugaagggcuaagcggggaaagaagacccuguug
aguuugacuccagucuggcucugugcggcgacuuacguugcuucacuuau
cgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccg
ucuaggcugacgcgugcggaacucugcgccaacgggguggaauucuccgg
agucuuguuucgagacaucugccagauggggaguuuggcuggggcggcau
aucuguuacacgacaacgcagguguccuaaggcgagcucagugggaucuc
acguggaacacaagcguaaaugcuugcuugauuaacgauuuccaguacga
aucgagacugcgaaagcaaggccagcgauccuuugcgaagaacaggaaau
augaacaaaucauaccagaggugucagaauaauuaccacagggauaacug
gcuuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgau
gucggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauugu
ucacccacugacagggaacgugagcuggguuuagaccgucgugagacagg
uugguuuuacccuacuuggcuggagauugcgaguaaaagauuauccgcgc
aaagcggaggcaguccguuuuuuucugggucugccguuggguggcaugug
cuuggcgcu
......................<<......>>......<<<<<...>>>>
>........<<<<....<<<<.<<<<.<<.........<.....<<<<<.
....<..>......>>>>><<.<<<<<<<<<<<>>>>>..>>>>>>.>>.
.........<<<<<<<<<..<<<.........>>>..<<<<<<<....<<
<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<.
...<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<.......>>>>>.....>..
...>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>..........
..<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<.<<
<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>...<
<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>>>.
....<..<...>..>...................<<<.<<..>>.>>>..
.>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>>..
<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<..>>>
>>.....<<......>>....>>>>>>>...<<...<<<<<.......>>
>>>..>>.<<<....>>>.>>.........<<<<<..............<
<<<.......>>>>.>>>>>..........>>>>..>>>>>>.......<
<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>.>......
.<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>>.<<<.....
....>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>
>>....>>..>>>.>>>>>>>.......................<<<<..
...>>>>...<<<...........>>>..........<..<.<.......
>.>.>....
Receptor-Ligand Complex Structure
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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
S2 H3 C4 K5 E7 R10 H11 P18 R19 K20 R21 R93 H109 Q135 R138 T139 R148 K151 K170 E207 R209 F231 G233 R237 K246 T247 H248 R249 G250 L251 R252 A255 C256 I257 A259 W260 H261 S263 R264 V265 T268 R271 A272 Q274 N326 D327
Binding residue
(residue number reindexed from 1)
S1 H2 C3 K4 E6 R9 H10 P17 R18 K19 R20 R92 H108 Q134 R137 T138 R147 K150 K169 E206 R208 F230 G232 R236 K245 T246 H247 R248 G249 L250 R251 A254 C255 I256 A258 W259 H260 S262 R263 V264 T267 R270 A271 Q273 N325 D326
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ581Q1

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