Structure of PDB 8ova Chain Bf Binding Site BS02

Receptor Information
>8ova Chain Bf (length=396) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRR
Ligand information
>8ova Chain BB (length=1119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguaugucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacuuacguugcuucacu
uaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcg
ccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauu
uccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaag
aacaggaaauaugaacaaaucauaccagaggugucagaauaauuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagg
guuggauuguucacccacugacagggaacgugagcuggguuuagaccguc
gugagacagguugguuuuacccuacuuggcuggagauugcgaguaaaaga
uuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguugg
guggcaugugcuuggcgcu
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>.
..<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>
>>...<.<..<...>..>>....................<<<.<..>.>>
>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<
<.......>>>>>..>>.<<<....>>>.>>.........<<<<<.....
.........<<<<.......>>>>.>>>>>..........>>>>..>>>>
>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>
>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....>>..>>>.>>>>>>>...................
....<<<<.....>>>>...<<<...........>>>..........<..
<.<.......>.>.>....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)
S2 H3 K5 E7 H8 P9 R10 H11 P18 R19 K20 R21 P83 R93 H109 Q135 R138 T139 R148 K151 R169 E207 R209 F231 G233 R237 K246 T247 H248 R249 G250 R252 A255 C256 G258 A259 W260 H261 S263 R264 V265 M266 T268 R271 A272 Q274 M296 N326 D327
Binding residue
(residue number reindexed from 1)
S1 H2 K4 E6 H7 P8 R9 H10 P17 R18 K19 R20 P82 R92 H108 Q134 R137 T138 R147 K150 R168 E206 R208 F230 G232 R236 K245 T246 H247 R248 G249 R251 A254 C255 G257 A258 W259 H260 S262 R263 V264 M265 T267 R270 A271 Q273 M295 N325 D326
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ581Q1

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