Structure of PDB 4v8m Chain Bf Binding Site BS02

Receptor Information
>4v8m Chain Bf (length=413) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHCKFEHPRHGHLGFLPRKRSRQIRGRARSFPKDDPSQKPHLTSFMVYKA
GMTHIVRDVDRPGSKVNKKEVVEPVTILEAPPMVVVGIVGYRQTPVGHKT
IGTVWAHHTSVEFRRRFYKNWKQSAQLAFTKRKQFARTTEGRLAEARTLK
AFEKKADIIRVVAHTQLRKLRNNRVGVKKAHVSEIQINGGTIAQKIELAK
SLLEKEVRIDSVFQQSEACDVCAVTKGHGFTGVVKRWGVACLPRKTHRGL
RKVACIGAWHPSRVMYTVARAGQHGYHHRTHLNKKIYQLGRAVSMEPNQA
TTAYDLTAKTITPMGGFVGYGTVRNDYVMLKGSVAGPRRRVITLRRPMAP
QTSRKLTEKITLKFIDTSSKIGHGRFQTKKEKSQWYGPLKKDRIRREERL
RKERAARAAERKA
Ligand information
>4v8m Chain BB (length=1465) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaa
ugcucugguaacauagagaaagguacacucagggaagucggcaaaauaga
ugcguaaguucgcaagaagcauuggcucugagggcaaaguggggguccac
aggagggccaguguccuuugaaggcuacccucccgagccguaucuacuaa
ccuccuucugguguguuguuuuuacgucucacucccgcgcagguguuuuc
gcuuccuuuuuuugguugcgcaccuacaaauugccaacucagaacugcuu
acggcggggaauccaacuguauaauuaaaacauagguuugugaugcaucc
aagugguguaugucgcaaacugauuucugcccagugcucugaaugucaac
gugagagauucaccgacgcgcggguaaacggcgggaguaacuaugacucu
cuuaagguagccaaaugccucgucuuccaauuagagacgcgcaugaaugg
auuaaugagauucccucugucccgaguuacuaucuagcgaaacgacaguc
aagggaacggacuugaagggcuaagcggggaaagaagacccuguugaguu
ugacuccagucuggcucugugcggcgacuuuggagguguaguauaggugg
aagcgcaagcucaaaugaaauaccaccacucggaacguugcuucacuuau
cgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccg
ucuaggcugggcauaauugugguguuucuuucaccgccacgggaggggug
uugguuuuuuauccuccucuccguuucuccuuuucucucuuucucccuuu
uuuugggcguuugaggguuggugacccgugggcgcccacgcgugcggaac
uacugcgccaacggggugggaacuuuucguuucuucuccggagucuuguu
ucgagacaucugccagauggggaguuuggcuggggcggcauaucuguuac
acgacaacgcagguguccuaaggcgagcucagugggaacagaaaucucac
guggaacacaagcguaaaugcuugcuugauuaacgauuuccaguacgaau
cgagacugcgaaagcaaggccagcgauccuuugcgaagaacaggaaauau
gaacaaaucauaccagaggugucagaauaauuaccacagggauaacuggc
uuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugu
cggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguuc
acccacugacagggaacgugagcuggguuuagaccgucgugagacagguu
gguuuuacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaa
agcggaggcaguccguuuuuuucugggucugccguucgguggcaugugcu
uggcgcugccaucuc
.........................<<......>>......<<<<<...>
>>>>.........<<<<....<<<..<<<<.<<...............<<
<<<...............>>>>><..<<<<<<<<<<<..<<<<<......
.<<<<<....<<<.<<<....>>>.>>>>>>>>.<<<.<<<<...<.<<<
<.............>>>>.>..>>>>.>>>..>>>>>.....<<<....<
<<..<<.......>>..>>>>>>.......>>>>>..>>>>>>..>....
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<..
.....>>>......>>>>>>>...<<..<<<..<<<<<......<<....
<<<<.....>>>>....>>...>>>..>>>>><<<<<<.......>>>>>
>....................<<<<<.......>>>>>...........>
>....>>.>>>>>>>.....>>.>>>>.>>>.>>>>............<<
<<<........>>>>>...<<<<<<..<<<.<<......<<<<.<..<<<
..<<<<..<<<<<<<...<<..<<<<<<<<..<............<<<<<
...<....>.............>>>>>...>..>>.>>>>>>..>>...<
<<<<.....<<<.....<...<<..<<<<<<<<<....>>>>>>>>>..>
.>>..<..<<<<........<<<<.......>>>>.<<<<<<<...<...
...<.......>..>..<<.<<<.<<<<<.....<.<<<...........
....>>>.>...>>>>>.>>>.>>>>>>>>>..>>>>.....>.......
...........<<<<<.<<<<<<.....>>>>>>.>>>>>...>>>...>
>>>>.......>>>>>>>...>>>>...<<.......>>..<<<<<<...
........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>
.....<<....((>>....>>>>>>>...<<..<<<<<<.......>>>>
>>.>>.<<<....>>>..))........<<<<<..............<<<
<.......>>>>.>>>>>..........>>>....>>>>>.......<<.
<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<
.<<<.<<<<<<..<<<<<<<.<......>.>>>>>..>>.<<<.......
..>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>
....>>..>>>.>>>>>>.......................<<<<<....
.>>>>><<<<<<<<<........>>>>.>>>>>....<<<<<<<.<<<<.
..>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB4v8m High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
Resolution5.57 Å
Binding residue
(original residue number in PDB)
S53 H54 C55 K56 F57 E58 H59 P60 R61 H62 P69 R70 K71 R72 H160 Q186 A188 R189 E192 K202 L222 R260 F282 T283 G284 R288 L294 R296 K297 H299 R300 L302 R303 K304 A306 C307 I308 G309 A310 W311 H312 S314 R315 V316 T319 A321 R322 G324 Q325 R376
Binding residue
(residue number reindexed from 1)
S1 H2 C3 K4 F5 E6 H7 P8 R9 H10 P17 R18 K19 R20 H108 Q134 A136 R137 E140 K150 L170 R208 F230 T231 G232 R236 L242 R244 K245 H247 R248 L250 R251 K252 A254 C255 I256 G257 A258 W259 H260 S262 R263 V264 T267 A269 R270 G272 Q273 R324
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4v8m, PDBe:4v8m, PDBj:4v8m
PDBsum4v8m
PubMed23395961
UniProtQ581Q1

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