Structure of PDB 8ove Chain BZ Binding Site BS02

Receptor Information

>8ove Chain BZ (length=120) Species: 5702 (Trypanosoma brucei brucei)

GIKCRNRRKARRAHFQAPSHVRRILMSAPLSKELRAKYNVRSMPVRKDDE
VRVKRGKFKGREGRVTACYRLKWVIHIDKVSCEKANGTTVPVGVHTSNVE
ITKLKLNTRRKAILERKDRS

Ligand information

>8ove Chain BC (length=160)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagc
aaagugcgauaagugguaucaauugcagaaucauugcccaaucuuugaac
gcaaacggcgcaugggagaagcucgagccauccccgugcaugccacauuu
cucagugucg

.........................................<<<<<<<<<
....>>>>.....(<<<<......>>........>>>>.)...>>>....
<<.....>><<<<<<<....<<<..>>>....>>>>>>>...........
..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): R10 R13 R14 F17 Q18 H22 R48 K49 Y71 R72 R111
• Binding residue (residue number reindexed from 1): R8 R11 R12 F15 Q16 H20 R46 K47 Y69 R70 R109

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0042273 ribosomal large subunit biogenesis

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit

External links

• PDB: RCSB:8ove, PDBe:8ove, PDBj:8ove
• PDBsum: 8ove
• PubMed: 37985661
• UniProt: Q38D25