Structure of PDB 8ove Chain BW Binding Site BS02

Receptor Information

>8ove Chain BW (length=129) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CRFRVSLALPVGAVVNCADNTGAKNLYIISVKGYHGRLNRLPAAALGDMV
MASVKKGKPELRRKVLNAVIIRQRKSWRRKDGTVIYFEDNAGVIVNPKGE
MKGSGIAGPVAKEAAELWPKISTHAPAIV

Ligand information

>8ove Chain BG (length=183) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gugagauugugaagggaucucgcaggcaucgugagggaaguaugggguag
uacgagaggaacucccaugccgugccucugguuucuggaguuugucgaag
ggcaagugcuccgacgcuaucgcacggugguucucggcugaacgccucua
agccagaaaccagucccaagaccgggugcccgu

<<<<<<<.........>>>>>>>.<<<<<<....<<<<.<<<<<<<<...
............>>>>>>>><<<<<...<<<<....<<<<<<<<<.....
.>>>>..>>>>>...>>>>..>>>>>.<<<<..<.<<<<...........
>>>>.>..>>>>.>>>>.......>>>>>>...

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	R12 F13 R14 R47 R50
Binding residue (residue number reindexed from 1)	R2 F3 R4 R37 R40

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003735	structural constituent of ribosome
GO:0070180	large ribosomal subunit rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum	8ove
PubMed	37985661
UniProt	Q38DP2

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