Structure of PDB 7am2 Chain BU Binding Site BS02

Receptor Information
>7am2 Chain BU (length=463) Species: 5689 (Leishmania tarentolae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAIVGRMNSGKSSLFNLLCEDPTMPAKKNIVKDFNGITRDCVEAHAALDD
LHFTVIDTPGLLGGKLVEEAFRTVETADAAIFVTAVDEDVSAEEHDLIQY
LAAKKMPTCLLVNKMDLVPEEEEALVLDVYNRLGLGKAVPFSARKREGLD
MLSALLEPLYHIHAMRKVENDWDIEDLAMAGDEAAMEEIRDRNCTDRYIR
VAIVGRTNSGKTSLVNRLVGYERNRAADESNTTRDPIEIACMYKGRKLKL
IDTAGLARQRYRTDREFLSRIHSLSLNEIRYAHVVIVVFDATEGHPNKYD
MSILHKVAQEGRPFVLCANKWDAVLDQSATAEAIDFKIKRQVQEVKYSNA
VVVSAHTGMNLTLLMDQVLELYDTWNKRVRRSELTKFWRKLEKSVIIPYH
VARVGRITQISTRPPTFLLQLQTKKEESQLPKALQEMMKNAITEEFGFRG
VPLRLVQEVKDSN
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain7am2 Chain BU Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7am2 Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		L248 V249 G250 Y251 Y273
Binding residue
(residue number reindexed from 1)		L218 V219 G220 Y221 Y243
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005739 mitochondrion
GO:0020023 kinetoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7am2, PDBe:7am2, PDBj:7am2
PDBsum7am2
PubMed33168716
UniProtQ4Q9G4

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