Structure of PDB 8ove Chain BT Binding Site BS02

Receptor Information
>8ove Chain BT (length=192) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKLQARLAADILRCGRGRVWLDPNEAVEIRNANSRKSVRKLIKDGLVMR
KPVKVHSRSRWRQMKLAKSMGRHEGTGRREGTREARMPSKDLWMRRLRIL
RRLLRKYREEKKIDRHIYRELYMKAKGNVFRNKRNLMEHIHKVKNEKKKA
RQLAEQLAAKRLKDEQNRRKARKQELKKREKERERARRDDAA
Ligand information
>8ove Chain BA (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggaccacccgcuaaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagucagcggcgagcgaagag
ggauucaacucguugccgaaucgggucuuauaugaccucgaacuguggca
uagggcuggugcaggcguggcggaauucaauugcaaagcaaacccguugc
ugaacauacaacccuucaugugaguauugagccaaagaaggugucagccc
auuacagccacggagccuacgcgccuccucaagagaguagcacuguuugg
gaaugcagugucaagccggcagguauuugucugccaagguuaaauauaga
guaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaagua
cuuuggaaagagagugacauagaaccugaaaucgugacaacgacaaugga
aguaccuucauuucucggccagacccaaccucgccgcgcaauuuccuucc
ggggcuaacauccgguggguacugugcggguuucgaggucauggggugcg
ugagugggcggaauaaagggucggugguuguguucuuccuccuucccugu
ccgugcgucucgacgcuggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggaguauugugac
aacuuuucucguacugaaagggaggugugauacacccguggcgugcgcaa
uuuguguuuuugcccaacaccgaccggcgugggcugcgcgcgagugugcc
uguuuggacccgaaagguggugaacuaugccugaacaaggugaagcccgg
ggaaaccccgguggaggccuguagcgaugcugacgugcaaaucgcucgua
cgauuuggguaucggagcgaaagacucaucgaaccaccuaguagcugguu
cacgucgaaguuucccucaggauagcuggugcuuguuaagaaguauugug
cgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugcaa
acaacccagccuuaguuauaacaaggcuggguaauugaggcaccaagugg
gccuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggau
auguggcgucaaaacuugugggcucauucucgauacgugaaaaggguguu
gguggauauccaccggccccgaaaauggaugacgcuuaagccccaugugc
gugauugcccauuauuccuuuggugagggcggcuauaugugagaaagugu
agcccucccgauguagacguggcgugggggugaggacgaagccgauggcg
cgagccucggauggacccgccucuagugcagaucuugguuggcguagcaa
agaucuaacggaauauuuuuaaaugcaacguuggauacuggagcggggaa
ggauuucgugccaacggcacucguacacgaguuguucggucacugagcac
aacguuacaccguuuuguuaggaaagaaaaggggcaacagagaaccuggg
augauauuccaaaaagaauugcauguggg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>...<<<<<......<<.....>>....>>
>>>....<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<<<<<<<......<<<......<<<<.......>>>
>.......<<........>>......>>>.<<.......((.....>>))
......>>>>>...>>>>..>>>>>.>>>..........<<<<<<<....
....>>>>>>>......<<<<<........>>>>>..>>>..........
..........................<<....>>................
<<<<....>>>>..................................<<<.
.<<<<<<.<<<<<..<<.<<<<.(<<<<<<<<<<<<<<<.....<<<.<<
<<<.......>>>>>.>>>....>>>>>>....>>>>>>..>>>......
........<<<<....<<<<..<<.<<..<....>..>>.>>..>>>>.>
>>>....<<<<<..)>>>>>>....>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<<........
.>>>...>>>...<<....>>..<<<<<...>>>>>......<...<.<.
......>.>....>.....<<<.<<......>>.>>.>.....>>>>>.>
>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<.<<
<....>>>.>>>.....>>>...<<<<.<<.<<........>>>>>>>>.
...>>>>>>>>>...<<.......>>......>>>>>>...>..>.>>..
.<<<<<....<.<<<....>>>.><<<<<<<<<.......<<.<.<<<<<
<....<<<....<<<....<<<..>>>....>>>..>.>>....>>>>>>
...<<<<<<<<<<.<<<..>>>>>>>>>>>>>.>>>..>>>>>>>.>>..
<<<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<
<...<<<(((......<<.<<<<........<...........<<<.<<<
<<<<<<..>>>>>>>>>>>>..........))).>....>>>>>>.....
......>>>...>>>>>>><<<<.<<<<<..........>>>>>......
..>>>>>>>>>....>>>>>..<.<<<<<<<<........<<<<..<<<.
...>>>.>>>.>.....>>>>>>>>..>.....>>>>>>...........
...<<<<<<<..................>>>>>>>...............
.....<<<<<....<<.....>>..>>>>>.....<..........<<.<
<<<<......>>>>.................>.>>..........<<<<.
........>>....>>.>...........
Receptor-Ligand Complex Structure
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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R9 R19 L24 P26 R38 R42 T84 E86 K92 W95 M125 K126 G129 N130
Binding residue
(residue number reindexed from 1)		R7 R17 L22 P24 R36 R40 T82 E84 K90 W93 M123 K124 G127 N128
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ57ZI7

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