Structure of PDB 4v8a Chain BT Binding Site BS02

Receptor Information
>4v8a Chain BT (length=131) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNRGALIKLVESRYVRTDLPEFRPGDTVRVSYKVKEGNRTRIQDFEGIVI
RIRRNGFNTTFTVRKVSYGVGVERIFPLHSPLIQKIDIVQRGRARRAKLY
FIRNLSDREIRRKLRADRKRIDQDRAAERAA
Ligand information
>4v8a Chain CA (length=1498) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaag
acaugcaagucgugcgggccgcgggcccguggucagcggcggacggguga
guaacgcgugggugaccuacccggaagagggggacaacccggggaaacuc
gggcuaaucccccauguggacccgccccuugggguguguccaaagggcuu
ugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaau
ggcccaccaaggcgacgacggguagccggucugagaggauggccggccac
aggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaa
ucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaaga
agcccuucgggguguaaacuccugaacccgggacgaaacccccgacgagg
ggacugacgguaccgggguaauagcgccggccaacuccgugccagcagcc
gcgguaauacggagggcgcgagcguuacccggauucacugggcguaaagg
gcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgu
gggggagcgugggauacgcucaggcuagacggugggagagggugguggaa
uucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggc
gaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgugggg
agcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgc
uaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgc
cuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggccc
gcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuu
accaggccuugacaugcuagggaacccgggugaaagccuggggugccccg
cgaggggagcccuagcacaggugcugcauggccgucgucagcucgugccg
ugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguug
ccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggagg
aaggaggggacgacgucuggucagcauggcccuuacggccugggcgacac
acgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcu
aaucgcaaaaaggugggcccaguucggauuggggucugcaacccgacccc
augaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaaua
cguucccgggccuuguacacaccgcccgucacgccaugggagcgggcucu
acccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgug
acuggggcgaagucguaacaagguagcuguaccggaaggugcggcugg
......<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<
<<.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<..
.....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>
>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<..
.>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.....
..>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>
.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>....
....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.....
.<<<<....>>>>.....>>>>....<<<<<......<.<<<<.....>>
>>..>.......>>>>>......<<<<<(((...<<<<<.....<<.)))
>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....
<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>
>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....
<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<
....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<
..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>
>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<
<.<<.<<<<<<..<<<<<<<<<<......<<........>>.........
.<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>.....<..
....>....>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<.
...>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<...
<...<<<.....>>>>.....>>>>>>>.....<<<<<....>>>>>...
.....>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>
>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>.
...>>>.....>>>>>>>.........<.<<<<<<<........>>>>>>
>>.........>>>>>>....<<<<<<<..........>>>>>>>.....
.>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<
<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>.
.>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v8a The antibiotic thermorubin inhibits protein synthesis by binding to inter-subunit bridge b2a of the ribosome.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E36 R39 R41 S106 R108 R111 R118 D122
Binding residue
(residue number reindexed from 1)		E36 R39 R41 S106 R108 R111 R118 D122
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v8a, PDBe:4v8a, PDBj:4v8a
PDBsum4v8a
PubMed22240456
UniProtP60490|RL19_THET8 Large ribosomal subunit protein bL19 (Gene Name=rplS)

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