Structure of PDB 8ova Chain BP Binding Site BS02

Receptor Information
>8ova Chain BP (length=152) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKANYIRAGRLVRILRGPRQNRVGVIVDIVDANRVLVENPCEQKMWRHVQ
NLKNVEPLKFCVSISRNCSTKALKEALESKKVLEKYAATKSAVRIAAKKA
FAESTDFERYQLRVAKRSRAYWARKIFDDNDKKNPVSWHKVALKKLLKNA
KK
Ligand information
>8ova Chain BB (length=1119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaau
gcucugguacauagagaaagguacacucagggaagucggcaaaauagaug
cguaaguucgcaagaagcauuggcucugagggcaaaaauugccaacucag
aacugcuuacggcggggaauccaacuguauaauuaaaacauagguuugug
augcauccaagugguguaugucgcaaacugauuucugcccagugcucugu
gucaacgugacgagauucaccgacgcgcggguaaacggcgggaguaacua
ugacucucuuaagguagccaaaugccucgucuuccaauuagagacgcgca
ugaauggauuaaugagauucccucugucccgaguuacuaucuagcgaaac
gacagucaagggaacggacuugaagggcuaagcggggaaagaagacccug
uugaguuugacuccagucuggcucugugcggcgacuuacguugcuucacu
uaucgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcg
ccgucuaggcugacgcgugcggaacuacugcgccaaacggggugguucuc
cggagucuuguuucgagacaucugccagauggggaguuuggcuggggcgg
cauaucuguuacacgacaacgcagguguccuaaggcgagcucagugggaa
cagaaaucucacguggaacacaagcguaaaugcuugcuugauuaacgauu
uccaguacgaaucgagacugcgaaagcaaggccagcgauccuuugcgaag
aacaggaaauaugaacaaaucauaccagaggugucagaauaauuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaaccuagcgccgcagaagacgcuaagg
guuggauuguucacccacugacagggaacgugagcuggguuuagaccguc
gugagacagguugguuuuacccuacuuggcuggagauugcgaguaaaaga
uuauccgcgcaaagcggaggcaguccguuuuuuucugggucugccguugg
guggcaugugcuuggcgcu
........................<<......>>......<<<<<...>>
>>>........<<<<....<<<<.<<<<.<<.........<.....<<<<
<.....<..>......>>>>><<.<<<<<<<<<<<...>>>>>..>>>>>
>.>>..........<<<<<<<<<..<<<.........>>>..<<<<<<<.
...<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<.<<
<<....<<<<......>>>>....>>>>>>>>..>>>>><<<<<<.....
..>>>>>>........<...........<<<<<.......>>>>>.....
>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>>.......
.....<<<<<........>>>>>..<<<<<<<..<<<.<<......<<<<
.<<<<<<..<<<<<.<<<<<<<...<<<.<<<<<<....>>>>>>.>>>.
..<<<<<.....<<<<....<<<......<<<<<<<......>>>>>>>>
>>...<.<..<...>..>>....................<<<.<..>.>>
>...>>>>...>>>>>.......>>>>>>>..>>>>>...<<<.....>>
>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.
......>>>>>>.....<<......>>....>>>>>>>...<<...<<<<
<.......>>>>>..>>.<<<....>>>.>>.........<<<<<.....
.........<<<<.......>>>>.>>>>>..........>>>>..>>>>
>>.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>.......<<<<<.<<<<<<..<<<<<<<.<......>.>>>>..>>
>.<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<
....>>>.>>>>....>>..>>>.>>>>>>>...................
....<<<<.....>>>>...<<<...........>>>..........<..
<.<.......>.>.>....
Receptor-Ligand Complex Structure
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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		K146 K152 K153
Binding residue
(residue number reindexed from 1)		K145 K151 K152
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ383F5

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