Structure of PDB 4v8m Chain BP Binding Site BS02

Receptor Information
>4v8m Chain BP (length=183) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKANYIRAGRLVRILRGPRQNRVGVIVDIVDANRVLVENPCEQKMWRHVQ
NLKNVEPLKFCVSISRNCSTKALKEALESKKVLEKYAATKVRRPHRAKKA
FAESTDFERYQLRVAKRSRAYWARKIFDENDKKNPVSWHKVALKKLLKNA
KKVDSTPAAKKRVEKARAARKARLAAGKSKTKV
Ligand information
>4v8m Chain BB (length=1465) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ucccaacugcagaccguacucaucaccgcaucagguccccaagcaucgaa
ugcucugguaacauagagaaagguacacucagggaagucggcaaaauaga
ugcguaaguucgcaagaagcauuggcucugagggcaaaguggggguccac
aggagggccaguguccuuugaaggcuacccucccgagccguaucuacuaa
ccuccuucugguguguuguuuuuacgucucacucccgcgcagguguuuuc
gcuuccuuuuuuugguugcgcaccuacaaauugccaacucagaacugcuu
acggcggggaauccaacuguauaauuaaaacauagguuugugaugcaucc
aagugguguaugucgcaaacugauuucugcccagugcucugaaugucaac
gugagagauucaccgacgcgcggguaaacggcgggaguaacuaugacucu
cuuaagguagccaaaugccucgucuuccaauuagagacgcgcaugaaugg
auuaaugagauucccucugucccgaguuacuaucuagcgaaacgacaguc
aagggaacggacuugaagggcuaagcggggaaagaagacccuguugaguu
ugacuccagucuggcucugugcggcgacuuuggagguguaguauaggugg
aagcgcaagcucaaaugaaauaccaccacucggaacguugcuucacuuau
cgaaugaagagaccaaugguuguuuugcgcagucuucgggcugugcgccg
ucuaggcugggcauaauugugguguuucuuucaccgccacgggaggggug
uugguuuuuuauccuccucuccguuucuccuuuucucucuuucucccuuu
uuuugggcguuugaggguuggugacccgugggcgcccacgcgugcggaac
uacugcgccaacggggugggaacuuuucguuucuucuccggagucuuguu
ucgagacaucugccagauggggaguuuggcuggggcggcauaucuguuac
acgacaacgcagguguccuaaggcgagcucagugggaacagaaaucucac
guggaacacaagcguaaaugcuugcuugauuaacgauuuccaguacgaau
cgagacugcgaaagcaaggccagcgauccuuugcgaagaacaggaaauau
gaacaaaucauaccagaggugucagaauaauuaccacagggauaacuggc
uuguggcggccaagcguucauagcgacgucgcuuuuugauccuucgaugu
cggcucuuccuaaccuagcgccgcagaagacgcuaaggguuggauuguuc
acccacugacagggaacgugagcuggguuuagaccgucgugagacagguu
gguuuuacccuacuuggcuggagauugcgaguaaaagauuauccgcgcaa
agcggaggcaguccguuuuuuucugggucugccguucgguggcaugugcu
uggcgcugccaucuc
.........................<<......>>......<<<<<...>
>>>>.........<<<<....<<<..<<<<.<<...............<<
<<<...............>>>>><..<<<<<<<<<<<..<<<<<......
.<<<<<....<<<.<<<....>>>.>>>>>>>>.<<<.<<<<...<.<<<
<.............>>>>.>..>>>>.>>>..>>>>>.....<<<....<
<<..<<.......>>..>>>>>>.......>>>>>..>>>>>>..>....
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<..
.....>>>......>>>>>>>...<<..<<<..<<<<<......<<....
<<<<.....>>>>....>>...>>>..>>>>><<<<<<.......>>>>>
>....................<<<<<.......>>>>>...........>
>....>>.>>>>>>>.....>>.>>>>.>>>.>>>>............<<
<<<........>>>>>...<<<<<<..<<<.<<......<<<<.<..<<<
..<<<<..<<<<<<<...<<..<<<<<<<<..<............<<<<<
...<....>.............>>>>>...>..>>.>>>>>>..>>...<
<<<<.....<<<.....<...<<..<<<<<<<<<....>>>>>>>>>..>
.>>..<..<<<<........<<<<.......>>>>.<<<<<<<...<...
...<.......>..>..<<.<<<.<<<<<.....<.<<<...........
....>>>.>...>>>>>.>>>.>>>>>>>>>..>>>>.....>.......
...........<<<<<.<<<<<<.....>>>>>>.>>>>>...>>>...>
>>>>.......>>>>>>>...>>>>...<<.......>>..<<<<<<...
........>>>>>>.......<<<<<<<...<<<<<<.......>>>>>>
.....<<....((>>....>>>>>>>...<<..<<<<<<.......>>>>
>>.>>.<<<....>>>..))........<<<<<..............<<<
<.......>>>>.>>>>>..........>>>....>>>>>.......<<.
<...<<<<<<...<<.......>>...>>>>>>....>.>.>.......<
.<<<.<<<<<<..<<<<<<<.<......>.>>>>>..>>.<<<.......
..>>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>
....>>..>>>.>>>>>>.......................<<<<<....
.>>>>><<<<<<<<<........>>>>.>>>>>....<<<<<<<.<<<<.
..>>>>>>>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v8m High-Resolution Cryo-Electron Microscopy Structure of the Trypanosoma Brucei Ribosome.
Resolution5.57 Å
Binding residue
(original residue number in PDB)		K126 S138 W139 L148 K152 K153 T157 P158 K162 R163 K166 A170 R171 R174
Binding residue
(residue number reindexed from 1)		K125 S137 W138 L147 K151 K152 T156 P157 K161 R162 K165 A169 R170 R173
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042273 ribosomal large subunit biogenesis
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:4v8m, PDBe:4v8m, PDBj:4v8m
PDBsum4v8m
PubMed23395961
UniProtP55842|RL14_TRYBB Large ribosomal subunit protein eL14

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