Structure of PDB 4u1v Chain BO Binding Site BS02

Receptor Information

>4u1v Chain BO (length=116) Species: 83333 (Escherichia coli K-12)

DKKSARIRRATRARRKLQELGATRLVVHRTPRHIYAQVIAPNGSEVLVAA
STVEKAIAEQLKYTGNKDAAAAVGKAVAERALEKGIKDVSFDRSGFQYHG
RVQALADAAREAGLQF

Ligand information

>4u1v Chain BB (length=119)

ugccuggcggccguagcgcgguggucccaccugaccccaugccgaacuca
gaagugaaacgccguagcgccgaugguaguguggggucuccccaugcgag
aguagggaacugccaggca

<<<<<<<<<<.....<<<<<<<<....<<<<<<<.............>>>
>..>>>...>>>>>>.>>.<<.......<<<<<<<<...>>>>>>>>...
....>>...>>>>>>>>>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4u1v Synergy of streptogramin antibiotics occurs independently of their effects on translation.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): K3 R15 R25 H29 R30 T31 R33 H34 Y36 Q38 I40 G44 S45 E46 V47 V54 E55 K63 Y64 N67 K68 Q98 H100 G101 R102
• Binding residue (residue number reindexed from 1): K2 R14 R24 H28 R29 T30 R32 H33 Y35 Q37 I39 G43 S44 E45 V46 V53 E54 K62 Y63 N66 K67 Q97 H99 G100 R101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4u1v, PDBe:4u1v, PDBj:4u1v
• PDBsum: 4u1v
• PubMed: 24957822
• UniProt: P0C018|RL18_ECOLI Large ribosomal subunit protein uL18 (Gene Name=rplR)