Structure of PDB 8oir Chain BH Binding Site BS02

Receptor Information

>8oir Chain BH (length=110) Species: 9606 (Homo sapiens)

AAPKNRRTIEVNRCRRRNPQKLIKVKNNIDVCPECGHLKQKHVLCAYCYE
KVCKETAEIRRQIGKQEGGPFKAPTIETVVLYTGETPSEQDQGKRIIERD
RKRPSWFTQN

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8oir Chain BH Residue 201

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8oir Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): C110 C123
• Binding residue (residue number reindexed from 1): C32 C45
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8oir, PDBe:8oir, PDBj:8oir
• PDBsum: 8oir
• PubMed: 37141370
• UniProt: Q9BYC8|RM32_HUMAN Large ribosomal subunit protein bL32m (Gene Name=MRPL32)