Structure of PDB 8oh8 Chain BBB Binding Site BS02

Receptor Information
>8oh8 Chain BBB (length=303) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMSQVTIKDIEVLNCEYGKNTIKFLRLHREGKKHFVKEVEVCTHLRLT
SAHEYLDGNNSFVIPTDTIKNIVLVLAKKNGISSIEQFAIDICKHFMTTF
CQVAYVKTYIQEVPWQRQYQNGVPHIHSFILVPDGIRFCEAEQCRNGPLV
VCAGIKDLKLMKTTQSGFEGFYRNEHTTLPERNDRILCGEFFCKWSYGEC
RDFDFDCIWSKVRECILEAFSGPPDCGEYSPSYQRTVNCIQMCVLSRVPQ
VQVIEVILNNNFYNVVDMKALGCTNDKEVLVPVETPYGSCACTLGRKKYL
EAQ
Ligand information
Ligand IDAZA
InChIInChI=1S/C4H3N5O2/c10-3-1-2(8-9-7-1)5-4(11)6-3/h(H3,5,6,7,8,9,10,11)
InChIKeyKVGVQTOQSNJTJI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC(=O)c2nn[nH]c2N1
OpenEye OEToolkits 1.5.0c12c([nH]nn1)NC(=O)NC2=O
ACDLabs 10.04O=C2Nc1nnnc1C(=O)N2
FormulaC4 H3 N5 O2
Name8-AZAXANTHINE
ChEMBLCHEMBL219341
DrugBankDB01875
ZINCZINC000018123155
PDB chain8oh8 Chain BBB Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8oh8 Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		F165 R182 S229 Y230 Q231
Binding residue
(residue number reindexed from 1)		F168 R185 S232 Y233 Q234
Annotation score2
Enzymatic activity
Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oh8, PDBe:8oh8, PDBj:8oh8
PDBsum8oh8
PubMed37695804
UniProtA0A8V0ZED1

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