Structure of PDB 8c3b Chain BBB Binding Site BS02

Receptor Information
>8c3b Chain BBB (length=124) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KETAAAKFERQHMDSSTSAASSSNYCNQMMKSRNLTKDRCKPVNTFVHES
LADVQAVCSQKNVACKNGQTNCYQSYSTMSITDCRETGSSKYPNCAYKTT
QANKHIIVACEGNPYVPVHFDASV
Ligand information
Ligand IDT9U
InChIInChI=1S/C5H9N2.H2O.O.Ru/c1-6-3-4-7(2)5-6;;;/h3-5H,1-2H3;1H2;;/q;;;+1/p-1
InChIKeyDEXKHQIKGXONQU-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CN1C=CN(C1[Ru](=O)O)C
CACTVS 3.385CN1C=CN(C)C1[Ru](O)=O
FormulaC5 H10 N2 O2 Ru
Name(1,3-dimethyl-2~{H}-imidazol-2-yl)-oxidanyl-oxidanylidene-ruthenium
ChEMBL
DrugBank
ZINC
PDB chain8c3b Chain BBB Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8c3b Ruthenium(II)-arene Complexes with Glycosylated Carbene Ligands: Synthesis, Characterization, Antiproliferative Activity, In Solution and Crystallographic Evidences of Macromolecule Binding
Resolution1.24 Å
Binding residue
(original residue number in PDB)		Q74 H105
Binding residue
(residue number reindexed from 1)		Q74 H105
Annotation score1
Enzymatic activity
Enzyme Commision number 4.6.1.18: pancreatic ribonuclease.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004522 ribonuclease A activity
GO:0004540 RNA nuclease activity
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c3b, PDBe:8c3b, PDBj:8c3b
PDBsum8c3b
PubMed
UniProtP61823|RNAS1_BOVIN Ribonuclease pancreatic (Gene Name=RNASE1)

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