Structure of PDB 7qf9 Chain BBB Binding Site BS02

Receptor Information
>7qf9 Chain BBB (length=149) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPK
KILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNS
TNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
Ligand information
Ligand IDCMT
InChIInChI=1S/C4H9NO2S/c1-7-4(6)3(5)2-8/h3,8H,2,5H2,1H3/t3-/m0/s1
InChIKeyMCYHPZGUONZRGO-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0COC(=O)[C@H](CS)N
CACTVS 3.341COC(=O)[C@@H](N)CS
CACTVS 3.341COC(=O)[CH](N)CS
ACDLabs 10.04O=C(OC)C(N)CS
OpenEye OEToolkits 1.5.0COC(=O)C(CS)N
FormulaC4 H9 N O2 S
NameO-METHYLCYSTEINE
ChEMBLCHEMBL1231844
DrugBank
ZINCZINC000019230196
PDB chain7qf9 Chain BBB Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7qf9 Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		I53 L54 V59 A111
Binding residue
(residue number reindexed from 1)		I52 L53 V58 A110
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005095 GTPase inhibitor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
Biological Process
GO:0007601 visual perception
GO:0050953 sensory perception of light stimulus
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qf9, PDBe:7qf9, PDBj:7qf9
PDBsum7qf9
PubMed35104933
UniProtO43924|PDE6D_HUMAN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (Gene Name=PDE6D)

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