Structure of PDB 8ipa Chain BB Binding Site BS02

Receptor Information

>8ipa Chain BB (length=119) Species: 4565 (Triticum aestivum)

VKAGELWNKSKDDLTKQLAELKTELGQLRIQKVASSGSKLNRIHDIRKSI
ARVLTVINAKQRAQLRLFYKNKKYAPLDLRAKQTRAIRRRLSPDEKSRVL
EKTKKRTVHFPQRKFAIKA

Ligand information

>8ipa Chain SB (length=160)

cgacucucggcaacggauaucucggcucucgcaucgaugaagaacguagc
gaaaugcgauaccuggugugaauugcagaaucccgugaaccaucgagucu
uugaacgcaaguugcgcccgaggccauccggccgagggcacgccugccug
ggcgucacgc

.........................................<<<<<<.((
.....>>>....<<<<<<<.....))............>.>>>>.>>..>
>>....<<.....>><<<<..<<<<....>>>>..>>>>...........
..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8ipa Boric acid intercepts 80S ribosome migration from AUG-stop by stabilizing eRF1.
• Resolution: 3.4 Å
• Binding residue (original residue number in PDB): K7 W12 K37 N46 H49 R52 A56 R57 L59 T60 N63 R67 R71 R85 K87 T89 R90 R93
• Binding residue (residue number reindexed from 1): K2 W7 K32 N41 H44 R47 A51 R52 L54 T55 N58 R62 R66 R80 K82 T84 R85 R88

Gene Ontology

Molecular Function

• GO:0003729 mRNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ipa, PDBe:8ipa, PDBj:8ipa
• PDBsum: 8ipa
• PubMed: 38267667
• UniProt: Q8L805|RL35_WHEAT Large ribosomal subunit protein uL29 (Gene Name=RPL35)