Structure of PDB 6lqp Chain B8 Binding Site BS02

Receptor Information
>6lqp Chain B8 (length=477) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPPDEEEQLLAKFVFGDTTDLQENLAKFNADFEAAWIDSDDEKIKVPILV
TNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDINALTK
ILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLSFHPSK
PLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLSNQNQQ
NIFTAGRRRYMHSWDLSLTAKIEKFSRLYGHESTQRSFENFKVAHLQNSQ
TNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQPISRG
KFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGGGTTTT
CPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALDQLTTT
ISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPLGKVTS
VAFSPSGGLLAVGNEQGKVRLWKLNHY
Ligand information
>6lqp Chain 5A (length=523) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgaaagcaguugaagacaaguggcuugucguucguuaaaauggccucg
ucaaacgguggagagagucgcuaggugaucgucagaucugccuagucucu
auacagcguguuuaauugacauggguugaugcguauugagagauacaauu
ugggaagaaauucccagaguguguuucuuuugcguuuaaccugaacaguc
ucaucgugggcaucuugcgauuccauuggugagcagcgaaggauuuggug
gauuacuagcuaauagcaaucuauuucaaagaauucaaacuugggggaau
gccuuguugaauagccggucgcaagacugugauucuucaaguguaaccuc
cucucaaaucagcgauaucaaacguaccaccgugaaacaccgggguaucu
guuugguggaaccugauuagaggaaacucaaagagugcuaugguauggug
acggagugcgcuggucaagaguguaaaagcuuuuugaacagagagcauuu
ccggcagcagagauuucagcugu
<<<....>>>...<<<<<<<<<<.>>>>>>>.>>>..............<
<<<<<<<.<<...<<<<..<<<<<<<<<<<....>>>>.>>>>>>>>>>>
...>>.>>>......>>>>>..<<<<<..........<<<<<<<<<<.<<
<<<<<<....>>>>>>>.>>>>>>>>>>>........>>>>>.......<
<<<<<<<<<<...........>>>>>.>>>>>>.................
........<<<...>>>.........................<<<<<..<
<<<<<<..<<<<...<<<<<....>>>>>.>.>>>..>>>>.>>.>>>>>
>.....<<<<<<...<<<<<<<<<<<<<.<<<........>>>>>>>.>.
>>>>>>>>....>>>>>>................................
.<<<<.<<<.<<<.<<<<<<<<......>>>>.>>>>.>>>...>>>..>
>>><<<<<.<<<..>>>.>>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqp Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		N141 K142 K144 K145 R147 Y150 Q167 D234 V236 R237 Q252 R317 R318 R319 Y320 K341 S343 R344 R353 S354 N380 R535 A536 K538 D539 N554 W555 T557 S558 G559 T560 P561 G563 K564 Q583
Binding residue
(residue number reindexed from 1)		N52 K53 K55 K56 R58 Y61 Q78 D124 V126 R127 Q142 R207 R208 R209 Y210 K224 S226 R227 R236 S237 N263 R418 A419 K421 D422 N437 W438 T440 S441 G442 T443 P444 G446 K447 Q466
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000292 RNA fragment catabolic process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6lqp, PDBe:6lqp, PDBj:6lqp
PDBsum6lqp
PubMed32943522
UniProtP40362|UTP18_YEAST U3 small nucleolar RNA-associated protein 18 (Gene Name=UTP18)

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