Structure of PDB 8r08 Chain B1 Binding Site BS02

Receptor Information
>8r08 Chain B1 (length=870) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERNRPLSDEELDAMFPEGYKVLNDQPSGNLPFLKPDDIQYFDKLLVDVDE
STLSPEEQKERKIMKLLLKIKNGTPPMRKAALRQITDKAREFGAGPLFNQ
ILPLLMSPTLEDQERHLLVKVIDRILYKLDDLVRPYVHKILVVIEPLLID
EDYYARVEGREIISNLAKAAGLATMISTMRPDIDNMDEYVRNTTARAFAV
VASALGIPSLLPFLKAVCKSKKSWQARHTGIKIVQQIAILMGCAILPHLR
SLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESFDSVLKPLWKG
IRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEM
KKIVLKVVKQCCGTDGVEANYIKTEILPPFFKHFWQHRMALDRRNYRQLV
DTTVELANKVGAAEIISRIVDDLKDEAEQYRKMVMETIEKIMGNLGAADI
DHKLEEQLIDGILYAFQEQTTEDSVMLNGFGTVVNALGKRVKPYLPQICG
TVLWRLNNKSAKVRQQAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGE
EYPEVLGSILGALKAIVNVIGMHKMTPPIKDLLPRLTPILKNRHEKVQEN
CIDLVGRIADRGAEYVSAREWMRICFELLELLKAHKKAIRRATVNTFGYI
AKAIGPHDVLATLLNNLKVQERQNRVCTTVAIAIVAETCSPFTVLPALMN
EYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDRDLVH
RQTASAVVQHMSLGVYGFGCEDSLNHLLNYVWPNVFETSPHVIQAVMGAL
EGLRVAIGPCRMLQYCLQGLFHPARKVRDVYWKIYNSIYIGSQDALIAHY
PRIYNDDKNTYIRYELDYIL
Ligand information
>8r08 Chain 2 (length=97) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucucggcaaguguaguaucuguucuuaucaguuuaauaucugaugg
auuuuuggagcaucgaccugguauugcaguaccuccaggaacggugc
...............................<<<<.<....>.>>>>...
.........<<<<<<.<<<<<.............>>>>>..>>>>>>
Receptor-Ligand Complex Structure
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PDB8r08 Structural insights into the cross-exon to cross-intron spliceosome switch
Resolution6.1 Å
Binding residue
(original residue number in PDB)		P509 E1064 A1068 H1069 P1257
Binding residue
(residue number reindexed from 1)		P75 E630 A634 H635 P823
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:1990935 splicing factor binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000398 mRNA splicing, via spliceosome
GO:0006338 chromatin remodeling
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:1903241 U2-type prespliceosome assembly
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005684 U2-type spliceosomal complex
GO:0005686 U2 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0034693 U11/U12 snRNP
GO:0071004 U2-type prespliceosome
GO:0071005 U2-type precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0110016 B-WICH complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r08, PDBe:8r08, PDBj:8r08
PDBsum8r08
PubMed38778104
UniProtO75533|SF3B1_HUMAN Splicing factor 3B subunit 1 (Gene Name=SF3B1)

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