Structure of PDB 6lqs Chain B1 Binding Site BS02

Receptor Information
>6lqs Chain B1 (length=806) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSDFKFSNLLGTVYRQGNITFSDDGKQLLSPVGNRVSVFDLINNKSFTFE
YEHRKNIAAIDLNKQGTLLISIDEDGRAILVNFKARNVLHHFNFKEKCSA
VKFSPDGRLFALASGRFLQIWKTPDVNKDRQFAPFVRHRVHAGHFQDITS
LTWSQDSRFILTTSKDLSAKIWSVDSEEKNLAATTFNGHRDYVMGAFFSH
DQEKIYTVSKDGAVFVWEFTKRKYSWRITKKHFFYANQAKVKCVTFHPAT
RLLAVGFTSGEFRLYDLPDFTLIQQLSMGQNPVNTVSVNQTGEWLAFGSS
KLGQLLVYEWQSESYILKQQGHFDSTNSLAYSPDGSRVVTASEDGKIKVW
DITSGFCLATFEEHTSSVTAVQFAKRGQVMFSSSLDGTVRAWDLIRYRNF
RTFTGTERIQFNCLAVDPSGEVVCAGSLDNFDIHVWSVQTGQLLDALSGH
EGPVSCLSFSQENSVLASASWDKTIRIWSIFGRSQQVEPIEVYSDVLALS
MRPDGKEVAVSTLKGQISIFNIEDAKQVGNIDCRKDIISGRFNQDRFTAK
NSERSKFFTTIHYSFDGMAIVAGGNNNSICLYDVPNEVLLKRFIVSRNMA
LNGTLEFLNSKKMTEAGSLDLIDDMRPEVRVTSVQFSPTANAFAAASTEG
LLIYSTNDTILFDPFDLDVDVTPHSTVEALREKQFLNALVMAFRLNEEYL
INKVYEAIPIKEIPLVASNIPAIYLPRILKFIGDFAIESQHIEFNLIWIK
ALLSASGGYINEHKYLFSTAMRSIQRFIVRVAKEVVNTTTDNKYTYRFLV
STDGSM
Ligand information
>6lqs Chain 5A (length=152) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgaaagcaguugaagacaaguggcuugucguucguuaauggccucgca
gcgaaggauuugguggauuacuagcuaauagcaaucuaggaaacucaaag
agugcuaugcggagugcgcgagagcauuuccggcagcagagauuucagcu
gu
<<<....>>>...<<<<<<<<<...>>>>>>.>>>...............
.......................<<<...>>>..................
.........<<<<<<<<......>>>>.>>>>.<<<<.<<<..>>>.>>>
>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6lqs Cryo-EM structure of 90 S small ribosomal subunit precursors in transition states.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R55 R78 H92 F93 N94 K96 W122 F133 A134 P135 F136 R140 H142 A143 W173 S174 D176 S177 K180 M621 N631 K633
Binding residue
(residue number reindexed from 1)		R54 R77 H91 F92 N93 K95 W121 F132 A133 P134 F135 R139 H141 A142 W172 S173 D175 S176 K179 M599 N609 K611
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0005515 protein binding
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000920 septum digestion after cytokinesis
GO:0006364 rRNA processing
GO:0030010 establishment of cell polarity
GO:0030490 maturation of SSU-rRNA
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome
GO:0032040 small-subunit processome
GO:0034388 Pwp2p-containing subcomplex of 90S preribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lqs, PDBe:6lqs, PDBj:6lqs
PDBsum6lqs
PubMed32943522
UniProtP25635|PWP2_YEAST Periodic tryptophan protein 2 (Gene Name=PWP2)

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