Structure of PDB 9ene Chain B Binding Site BS02

Receptor Information
>9ene Chain B (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRAFDFSAHGRRHVALRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTR
LVESRQTSNYHRCGRTAKGVSAFGQVISLDLRSQFPEEIRYTHILNRVLP
PDIRILAWAPVEPSFSARFSCLERTYRYFFPRADLDIVTMDYAAQKYVGT
HDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQEPFQLCQFEV
TGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVE
FPLVLYDCKFENVKWIYDQEAQEFNITHLQQLWANHAVKTHMLYSMLQGL
DTVPSVIKQTSAFVMRTYKPLMDRPKCQG
Ligand information
>9ene Chain D (length=73) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcucuguggcgcaauggauagcgcauuggacuucuaauucaaagguugu
ggguucgagucccaccagagucg
<<<<<<<..<<<<........>>>>.<<<...........>>>.....<<
<<<.......>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB9ene The molecular basis of tRNA selectivity by human pseudouridine synthase 3.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		R113 R116 K119 R187 K227 N236 T240 Y276 R409 Q421
Binding residue
(residue number reindexed from 1)		R62 R65 K68 R118 K158 N167 T171 Y207 R316 Q328
Gene Ontology
Molecular Function
GO:0009982 pseudouridine synthase activity
GO:0016853 isomerase activity
GO:0160154 tRNA pseudouridine(38/39) synthase activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0031119 tRNA pseudouridine synthesis
GO:1990481 mRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9ene, PDBe:9ene, PDBj:9ene
PDBsum9ene
PubMed38996458
UniProtQ9BZE2|PUS3_HUMAN tRNA pseudouridine(38/39) synthase (Gene Name=PUS3)

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