Structure of PDB 9b8y Chain B Binding Site BS02

Receptor Information
>9b8y Chain B (length=978) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EQSWIPKIFKKKTCTTFIVTLCQCGRPRTAHPAVATVWDSDAHTTEKPTD
AYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLG
GSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDH
QMASKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDY
NYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLL
IDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDQGEARDRIRR
FFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGS
SEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDR
PEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQAPPDVGHV
LRMLLGKMAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRV
MARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPL
WGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFF
CPPLIYTRLITFRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLV
DFQPAPPGSLELLLYFWAFTLLCEELRQGLSGSLSQRLRLYLADSWNQCD
LVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGP
KIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFY
RPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANW
LVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIRE
FHSRPALAPPFIVISHLRLLKEAERKLLTWESVHKENFLLARARDKRESD
SERLKRTSQKVDLALKQLGHIREYEQRL
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain9b8y Chain B Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9b8y Physiological Temperature Drives TRPM4 Ligand Recognition and Gating
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D270 A392 D395 E396
Binding residue
(residue number reindexed from 1)		D243 A355 D358 E359
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005272 sodium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0002250 adaptive immune response
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008284 positive regulation of cell population proliferation
GO:0010460 positive regulation of heart rate
GO:0016925 protein sumoylation
GO:0019722 calcium-mediated signaling
GO:0030502 negative regulation of bone mineralization
GO:0034220 monoatomic ion transmembrane transport
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045907 positive regulation of vasoconstriction
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0071318 cellular response to ATP
GO:0086045 membrane depolarization during AV node cell action potential
GO:0086047 membrane depolarization during Purkinje myocyte cell action potential
GO:0086048 membrane depolarization during bundle of His cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098662 inorganic cation transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:1903949 positive regulation of atrial cardiac muscle cell action potential
GO:1904179 positive regulation of adipose tissue development
GO:1904199 positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization
Cellular Component
GO:0005654 nucleoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034706 sodium channel complex
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:9b8y, PDBe:9b8y, PDBj:9b8y
PDBsum9b8y
PubMed38750366
UniProtQ8TD43|TRPM4_HUMAN Transient receptor potential cation channel subfamily M member 4 (Gene Name=TRPM4)

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