Structure of PDB 8z90 Chain B Binding Site BS02

Receptor Information
>8z90 Chain B (length=710) Species: 126796 (Thogoto virus (isolate SiAr 126)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLFTPLSEINPTTTQELLYAYTGPAPVAYGTRTRAVLENIIRPYQYFYK
EPNVQRALDIKTGCKEPEDINVEGPSSGFHTASVLKLADNFFRKYRPAME
KLKYWILVKLPKLKYAELSKGRQTYSFIHKRNLPAPIALEETVEFLEQNL
RRKIGPTLLSYCQAIADVMELDETTYEGARDPRPWDIQLEEIDSDEEDPL
FRQVGREETYTIKFSREELWDQMRTLNTMWKHLERGRLNRRTIATPSMLI
RGFVKIVEDAAKEILENVPTSGVPVGGEEKLAKLASKQTFHTAVTGELSG
DQEKFNECLDPDAMRLMWTVFLRKLGCPDWIMELFNIPFMVFKSKLADMG
EGLVYTKGKLTDRKPLGEMPSEFDDLVRNVVGNSISCRLGMFMGMYNLTS
TLLALISIEREELTGSHVESSDDFIHFFNCKTHEEMFKQAETLRLTLKLV
GINMSPSKCILISPAGIGEFNSKFHHRDFVGNVATELPALVPNGTNPMTD
LAMGLNVIKHSVNTGQMNLCTGALAMRIFNHAYKYAYMALGVTRRTRFME
ENAITPLLTNQGASPVHSFSTMHLDEVALRRHLGLLDEETLRRILNPNNP
VTQKGDPSMFFRIENKMPQIMEDYSVPSCFKYTLSRNRTIQDKPHKALLN
KEERYQRVTSIINKLFPEVLIQEASAPGTVRESLKRRLELVVERSDLDEE
RKKRILSRIF
Ligand information
Receptor-Ligand Complex Structure
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PDB8z90 Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
Resolution2.87 Å
Binding residue
(original residue number in PDB)		R33 R122 Q123 R131 N132 M229 H232 I243 T245 E351 G394 M395 N397 R612 N615 K616 M617 P618 N637 R638 T639 Q641 K643 H645
Binding residue
(residue number reindexed from 1)		R33 R122 Q123 R131 N132 M229 H232 I243 T245 E351 G394 M395 N397 R612 N615 K616 M617 P618 N637 R638 T639 Q641 K643 H645
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:8z90, PDBe:8z90, PDBj:8z90
PDBsum8z90
PubMed38816392
UniProtO41353|RDRP_THOGV RNA-directed RNA polymerase catalytic subunit (Gene Name=Segment)

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