Structure of PDB 8yrs Chain B Binding Site BS02

Receptor Information

>8yrs Chain B (length=530) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLV
MPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLN
ASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARR
FTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVL
TDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRY
KGQSGIIYCFSQKDSEQVTVSLQNLGIHAGAYHANLEPEDKTTVHRKWSA
NEIQVVVATVAFGMGIDKPDVRFVIHHSMSKSMENYYQESGRAGRDDMKA
DCILYYGFGDIFRISSMVVMENVGQQKLYEMVSYCQNISKCRRVLMAQHF
DEVWNSEACNKMCDNCCKGSAFERKNITEYCRDLIKILKQAEELNEKLTP
LKLIDSWMGKGAAKLRVAGVVAPTLPREDLEKIIAHFLIQQYLKEDYSFT
AYATISYLKIGPKANLLNNEAHAITMQVTK

Ligand information

>8yrs Chain D (length=24) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ggtattggatctcgacgctctccc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8yrs Crystal structure of human RECQ1 helicase containing a flexible linker in complex with tailed duplex DNA
Resolution	2.43 Å
Binding residue (original residue number in PDB)	Q324 K325 A346 V372 A373 M429 Y574 T576
Binding residue (residue number reindexed from 1)	Q262 K263 A284 V310 A311 M367 Y502 T504

External links

PDB	RCSB:8yrs, PDBe:8yrs, PDBj:8yrs
PDBsum	8yrs
PubMed
UniProt	P46063\|RECQ1_HUMAN ATP-dependent DNA helicase Q1 (Gene Name=RECQL)

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