Structure of PDB 8w2o Chain B Binding Site BS02

Receptor Information
>8w2o Chain B (length=178) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYRNKARDIINKHNHK
RRHIGKRGRKERENSSQNETLKVTCLSNKEKRHIMHVKKMNQKELAQTSI
DTLKLLYDGSPGYSKVFVDANRFDIGDLVKRAQTSRSRDETCESNPFPRL
NNPKKLEPPKILSQWSNTIPKTSIFYSV
Ligand information
>8w2o Chain R (length=327) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
accuuaagauaucagaggaaaguccuacugaucaaacaugcgcuuccaau
aguagaaggacguuaagcauuuaucauugaacuguucauugaagucauug
augcaaacuccuuggucacacacacauacggcgcggaaggcguguuugcu
gacguuuccauucccuuguuucaaucauugguuaaacugauuuuuggggc
ccuuuguuucuucugccuggagaaguuugacaccaaauucaaauuggugu
uaggggagcuggggccuuucaaaaaaauuuuggaaggucuugguaggaac
ggguggaucuuauaauuuuugauuuau
.....<<<<.<<<<<<<<.....>>>.>>>>><<<<<<<<<.<<<<<...
.....<<<<<.<<<..<<<<.<.<<<.<<<<<.>>>>>.>>>.......>
>>>>.>>>>>>>>.....................>>>>>>>>>>>>>><<
<.<<<<.<<..<<<<<.<<<<<<<..<<<<<<<.>>>>>>>..>>>>>>>
((.......<<<<<....))>>>>>...<<<<<<<<.<....>>>>>>>>
>.>>>>><<<<<<<<<<<<<<<<<...>>>>>>>>>>>>>>>>>.>>>>>
>..>>>.>>>>................
Receptor-Ligand Complex Structure
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PDB8w2o Selected humanization of yeast U1 snRNP leads to global suppression of pre-mRNA splicing and mitochondrial dysfunction in the budding yeast.
Resolution3.49 Å
Binding residue
(original residue number in PDB)		H15 D36 Y37 R39 N40 K41 R43 H49 H51 K52 R54 H55 G57 K58 G60 R61 K62 E63 R64 C77 N80 K83 R84 M87
Binding residue
(residue number reindexed from 1)		H13 D34 Y35 R37 N38 K39 R41 H47 H49 K50 R52 H53 G55 K56 G58 R59 K60 E61 R62 C75 N78 K81 R82 M85
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0008270 zinc ion binding
GO:0030619 U1 snRNA binding
GO:0030627 pre-mRNA 5'-splice site binding
GO:0046872 metal ion binding
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8w2o, PDBe:8w2o, PDBj:8w2o
PDBsum8w2o
PubMed38688558
UniProtQ05900|RU1C_YEAST U1 small nuclear ribonucleoprotein C (Gene Name=YHC1)

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