Structure of PDB 8uh6 Chain B Binding Site BS02

Receptor Information
>8uh6 Chain B (length=386) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIP
GQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYA
YREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPST
MSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRW
LYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDV
LRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLC
GPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKI
CASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8uh6 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uh6 Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		C323 C394
Binding residue
(residue number reindexed from 1)		C280 C351
Annotation score4
External links
PDB RCSB:8uh6, PDBe:8uh6, PDBj:8uh6
PDBsum8uh6
PubMed39152201
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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