Structure of PDB 8twe Chain B Binding Site BS02

Receptor Information
>8twe Chain B (length=423) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NDIQWCFSQVKGAAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQEHS
RGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDK
TIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEAS
PRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDI
KPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSK
LFEEPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPV
ETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFD
RNTKRDITLEASRENNKPRTVLKPRKVCARKKDEISVDSLDFNKKILHTA
WHPKENIIAVATTNNLYIFQDKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8twe Real-space refinement in PHENIX for cryo-EM and crystallography.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		D197 K218 M222 T226 Y337 D340 F343
Binding residue
(residue number reindexed from 1)		D180 K201 M205 T209 Y317 D320 F323
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019888 protein phosphatase regulator activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0043278 response to morphine
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0045202 synapse
GO:0098978 glutamatergic synapse

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8twe, PDBe:8twe, PDBj:8twe
PDBsum8twe
PubMed38123684
UniProtP63151|2ABA_HUMAN Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (Gene Name=PPP2R2A)

[Back to BioLiP]