Structure of PDB 8tkz Chain B Binding Site BS02

Receptor Information

>8tkz Chain B (length=429) Species: 4896 (Schizosaccharomyces pombe)

SMGLKLLHPPKPYAMTSDPESYASVCVMKKWPIIATNVIDEVSRNISKAL
EAGMSDKAAYVTQGKEIISLLNQLKYDLQHNRPLKPLVGQGPDIDDYNEE
LEQVGPLTWGDAPWLYAGCYFYRIMSLFFQARSEWNRHDPFFEQKDFTLR
SSKSAIEEFAKRYVHLNSELASIQENKDDKAAYMIFVEMAEISLWGNAQS
LQGQKAVEESQKNILVNDFPKIWSKLSKVRHGRIDFVLNNAGFELFVDLL
FATYLLKTEIAETIILHPKDVPWFVSDVLVNDIPHLFNSLTSYFSGEGVQ
KLASDLAEFHAEGKIVIRPNPFWTTAHYFGRLPDVAPKLLSDLEQSDMVI
FKGDLNFRKLTGDCEWPHTTPFAEALGPIAGKFNILALRTIKADVVVGLG
KGVYEEIAKDNPHWERTGKYAVVEFCPKD

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 8tkz Chain B Residue 510

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8tkz Structure of fission yeast Duf89 protein bound to Co2+ and PO4
• Resolution: 2.06 Å
• Binding residue (original residue number in PDB): S0 E98 E101
• Binding residue (residue number reindexed from 1): S1 E99 E102
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004427 inorganic diphosphate phosphatase activity
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding
• GO:0097023 fructose 6-phosphate aldolase activity
• GO:0103026 fructose-1-phosphatase activity

Biological Process

• GO:0006974 DNA damage response
• GO:0030643 intracellular phosphate ion homeostasis
• GO:1990748 cellular detoxification

Cellular Component

• GO:0005634 nucleus
• GO:0005829 cytosol

External links

• PDB: RCSB:8tkz, PDBe:8tkz, PDBj:8tkz
• PDBsum: 8tkz
• UniProt: O94725|ART1B_SCHPO Damage-control phosphatase SPCC1393.13 (Gene Name=SPCC1393.13)