Structure of PDB 8t03 Chain B Binding Site BS02

Receptor Information
>8t03 Chain B (length=199) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VAKLLLPTLSSLAFLPTVSIATKRRFYMEAMVYLFTMFFVAFSHACDGPG
LSVLCFMRRDILEYFSIYGTALSMWVSLMALADFDEPQRSTFTMLGVLTI
AVRTFHDRWGYGVYSGPIGTATLIIAVKWLKKMKEKKGLYPDKSIYTQQI
GPGLCFGALALMLRFFFEEWDYTYVHSFYHCALAMSFVLLLPKVNKKAG
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain8t03 Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8t03 Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		W79 L99 T103 R107 G116 G120 T124
Binding residue
(residue number reindexed from 1)		W75 L95 T99 R103 G112 G116 T120
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0007517 muscle organ development
GO:0007520 myoblast fusion
GO:0014905 myoblast fusion involved in skeletal muscle regeneration
GO:0043403 skeletal muscle tissue regeneration
GO:0045026 plasma membrane fusion
GO:1904206 positive regulation of skeletal muscle hypertrophy
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8t03, PDBe:8t03, PDBj:8t03
PDBsum8t03
PubMed37770716
UniProtQ9D1N4|MYMK_MOUSE Protein myomaker (Gene Name=Mymk)

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