Structure of PDB 8szi Chain B Binding Site BS02

Receptor Information
>8szi Chain B (length=802) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFR
WLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNK
HIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSF
LRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEER
DICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEI
VRRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREF
LKKVHPRKSVHNGFAKEFWEETFNCHLQERPLCTGDENISSVETPYIDYT
HLRISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLK
HLRHLNFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYN
VYAKKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCC
FECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKEIEFLSWTEPF
GIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCF
SSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKNLQ
FLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALG
FLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPA
YASTYGKFVSAVEVIAILAASFGLLACIFFNKIYIILFKPSRNTIEEVRC
ST
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8szi Chain B Residue 1405 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8szi Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor
Resolution3.5 Å
Binding residue
(original residue number in PDB)		N82 L88 L91
Binding residue
(residue number reindexed from 1)		N63 L69 L72
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8szi, PDBe:8szi, PDBj:8szi
PDBsum8szi
PubMed38326620
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

[Back to BioLiP]