Structure of PDB 8r32 Chain B Binding Site BS02

Receptor Information

>8r32 Chain B (length=252) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RSLIVTTILEEPYVLFKKSLYGNDRFEGYCIDLLRELSTILGFTYEIRLV
EDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPF
MTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYD
KMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLT
QIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG
CP

Ligand information

Ligand ID

2J9

InChI

InChI=1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2

InChIKey

FLTMTBPCYAZIKM-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 12.01	Fc1ccc2c(c1)S(=O)(=O)NCN2C3CC3
CACTVS 3.385	Fc1ccc2N(CN[S](=O)(=O)c2c1)C3CC3
OpenEye OEToolkits 1.7.6	c1cc2c(cc1F)S(=O)(=O)NCN2C3CC3

Formula

C10 H11 F N2 O2 S

Name

4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide

PDB chain

8r32 Chain B Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8r32 The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.
Resolution	1.6 Å
Binding residue (original residue number in PDB)	P532 S761 K762 G763
Binding residue (residue number reindexed from 1)	P99 S208 K209 G210
Annotation score	1

External links

PDB	RCSB:8r32, PDBe:8r32, PDBj:8r32
PDBsum	8r32
PubMed	38369668
UniProt	P42260\|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

[Back to BioLiP]