Structure of PDB 8p0k Chain B Binding Site BS02

Receptor Information
>8p0k Chain B (length=1155) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EMDQRLGYKFLVPDPKAGVFYRPLHFQYVSYSNFILHRLHEILTVKRPLL
SFKNNTERIMIEISNVKVTPPDYSPIIASIKGKSYDALATFTVNIFKEVM
TKEGISITKISSYEGKDSHLIKIPLLIGYGNKNPLDTAKYLVPNVIGGVF
INKQSVEKVGINLVEKITTWPKFRVVKPNSFTFSFSSVSPPNVLPTRYRH
YKISLDISQLEALNISSTKTFITVNIVLLSQYLSRVSLEFIRRSLSYDMP
PEVVYLVNAIIDSAKRITESITDFNIDTYINDLVEAEHIKQKSQLTINEF
KYEMLHNFLPHMNYTPDQLKGFYMISLLRKFLYCIFHTSRYPDRDSMVCH
RILTYGKYFETLAHDELENYIGNIRNDIMNNHKNRGTYAVNIHVLTTPGL
NHAFSSLLSGKFKKSDGSYRTHPHYSWMQNISIPRSVGFYPDQVKISKMF
SVRKYHPSQYLYFCSSDVPERGPQVGLVSQLSVLSSITNILTSEYLDLEK
KICEYIRSYYKDDISYFETGFPITIENALVASLNPNMICDFVTDFRRRKR
MGFFGNLEVGITLVRDHMNEIRINIGAGRLVRPFLVVDNGELMMDVCPEL
ESRLDDMTFSDIQKEFPHVIEMVDIEQFTFSNVCESVQKFRMMSKDERKQ
YDLCDFPAEFRDGYVASSLVGINHNSGPRAILGCAQAKQAISCLSSDIRN
KIDNGIHLMYPERPIVISKALETSKIAANCFGQHVTIALMSYKGINQEDG
IIIKKQFIQRGGLDIVTAKKHQVEIPLENFNNKERDRSNAYSKLESNGLV
RLNAFLESGDAMARNISSRTLEDDFARDNQISFDVSEKYTDMYKSRVERV
QVELTDKVKVRVLTMKERRPILGDKFTTRTSQKGTVAYVADETELPYDEN
GITPDVIINSTSIFSRKTISMLIEVILTAAYSAKPYNNKGENRPVCFPSS
NETSIDTYMQFAKQCYEHSNPKLSDEELSDKIFCEKILYDPETDKPYASK
VFFGPIYYLRLRHLTQDKATVRCRGKKTKLIRQANEGRKRGGGIKFGEME
RDCLIAHGAANTITEVLKDSEEDYQDVYVCENCGDIAAQIKGINTCLRCS
KLNLSPLLTKIDTTHVSKVFLTQMNARGVKVKLDFERRPPSFYKPLDKVD
LKPSF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8p0k Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8p0k Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target)
Resolution2.64 Å
Binding residue
(original residue number in PDB)		C1087 C1090 C1103 C1106
Binding residue
(residue number reindexed from 1)		C1080 C1083 C1096 C1099
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006360 transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p0k, PDBe:8p0k, PDBj:8p0k
PDBsum8p0k
PubMed
UniProtP68694|RP132_VACCC DNA-directed RNA polymerase 133 kDa polypeptide (Gene Name=OPG151)

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