Structure of PDB 8og4 Chain B Binding Site BS02

Receptor Information
>8og4 Chain B (length=710) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLPIRLLPEKLPPPKATRGCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFG
SYLDPLVKQAFQATARANVYVTENADIACLYVILVGEMQEPVVLRPAELE
KQLYSLPHWRTDGHNHVIINLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQ
YRPGFDLVVSPLVHAMSEPNFMEIPPQVPVKRKYLFTFQGEKIADYDDRI
IATLKAVQDSKLDQVLVEFTCKNQPKPSLPTEWALCGEREDRLELLKLST
FALIITPGDPRLVISSGCATRLFEALEVGAVPVVLGEQVQLPYQDMLQWN
EAALVVPKPRVTEVHFLLRSLSDSDLLAMRRQGRFLWETYFSTADSIFNT
VLAMIRTRIQIPAAPIREEAAAEIPHRSGKETEPPYASPRYLRNFTLTVT
DFYRSWNCAPGPFHLFPHTPFDPVLPSEAKFLGSGTGFRPIGGGAGGSGK
EFQAALGGNVPREQFTVVMLTYEREEVLMNSLERLNGLPYLNKVVVVWNS
PKLPSEDLLWPDIGVPIMVVRTEKNSLNNRFLPWNEIETEAILSIDDDAH
LRHDEIMFGFRVWREARDRIVGFPGRYHAWDIPHQSWLYNSNYSCELSMV
LTGAAFFHKYYAYLYSYVMPQAIRDMVDEYINCEDIAMNFLVSHITRKPP
IKVTSRWTFDDSHFHERHKCINFFVKVYGYMPLLYTQFRVDSVLFKTRLP
HDKTKCFKFI
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8og4 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8og4 Molecular mechanism of decision-making in glycosaminoglycan biosynthesis
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D744 D746
Binding residue
(residue number reindexed from 1)		D546 D548
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0005515 protein binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0016500 protein-hormone receptor activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0045617 negative regulation of keratinocyte differentiation
GO:0050728 negative regulation of inflammatory response
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0106015 negative regulation of inflammatory response to wounding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000972 positive regulation of detection of glucose
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8og4, PDBe:8og4, PDBj:8og4
PDBsum8og4
PubMed37828045
UniProtO43909|EXTL3_HUMAN Exostosin-like 3 (Gene Name=EXTL3)

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