Structure of PDB 8kgn Chain B Binding Site BS02

Receptor Information
>8kgn Chain B (length=1180) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SISDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSNPSGPSF
DFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQGIVQVL
GLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYFHLFWPQ
LIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSLANHTVK
YYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGESELRKR
ELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQIPNFLD
GMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDMSLNTSI
IKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLASEFIKT
MFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWA
RQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNFKGHLKR
FGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNRMTFIEE
IIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLRNCLHSH
LNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKLRIIMET
AIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPEFASIEE
LNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVEQLLQES
PFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kgn Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution5.9 Å
Binding residue
(original residue number in PDB)		V473 M475 N476 K547 L551 S657 R660 K661 Y800 P852 S853 E854 G855 W856 K857 R1004 H1010 H1012
Binding residue
(residue number reindexed from 1)		V461 M463 N464 K535 L539 S645 R648 K649 Y788 P840 S841 E842 G843 W844 K845 R992 H998 H1000
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgn, PDBe:8kgn, PDBj:8kgn
PDBsum8kgn
PubMed38816407
UniProtA0A2X0THW2

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