Structure of PDB 8kgm Chain B Binding Site BS02

Receptor Information
>8kgm Chain B (length=1186) Species: 10497 (African swine fever virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFEISDFKEHAKKKSMWAGALNKVTISGLMGVFTEDEDLMALPIHRDHCP
ALLKIFDEIIVNATDHERACHNKTKKVTYIKISFDKGVFSCENDGPGIPI
AKHEQASLIAKRDVYVPEVASCHFLAGTNINKAKDCIKGGTNGVGLKLAM
VHSQWAILTTADGAQKYVQHINQRLDIIEPPTITPSREMFTRIELMPVYQ
ELGYAEPLSETEQADLSAWIYLRACQCAAYVGKGTTIYYNDKPCRTGSVM
ALAKMYTLLSAPNSTIHTATIKADAKPYSLHPLQVAAVVSPKFKKFEHVS
VINGVNCVKGEHVTFLKKTINEMVVKKFQQTIKDKNRKTTLRDSCSNIFI
VIVGSIPGIEWTGQRKDELSIAENVFKTHYSIPSSFLTSMTKSIVDILLQ
SISKKDNHVDKYTRARNAGGKRAQDCMLLAAEGDSALSLLRTGLTLGKSN
PSGPSFDFCGMISLGGVIMNACKKVTNITTDSGETIMVRNEQLTNNKVLQ
GIVQVLGLDFNCHYKTQEERAKLRYGCIVACVDQDLDGCGKILGLLLAYF
HLFWPQLIIHGFVKRLLTPLIRVYEKGKTMPVEFYYEQEFDAWAKKQTSL
ANHTVKYYKGLAAHDTHEVKSMFKHFDNMVYTFTLDDSAKELFHIYFGGE
SELRKRELCTGVVPLTETQTQSIHSVRRIPCSLHLQVDTKAYKLDAIERQ
IPNFLDGMTRARRKILAGGVKCFASNNRERKVFQFGGYVADHMFYHHGDM
SLNTSIIKAAQYYPGSSHLYPVFIGIGSFGSRHLGGKDAGSPRYISVQLA
SEFIKTMFPAEDSWLLPYVFEDGQRAEPEYYVPVLPLAIMEYGANPSEGW
KYTTWARQLEDILALVRAYVDKDNPKHELLHYAIKHKITILPLRPSNYNF
KGHLKRFGQYYYSYGTYVISEQRNIITITELPLRVPTVAYIESIKKSSNR
MTFIEEIIDYSSSETIEILVKLKPNSLNRIVEEFKETEEQDSIENFLRLR
NCLHSHLNFVKPKGGIIEFNTYYEILYAWLPYRRELYQKRLMREHAVLKL
RIIMETAIVRYINESAELNLSHYEDEKEASRILSEHGFPPLNHTLIISPE
FASIEELNQKALQGCYTYILSLQARELLIAAKTRRVEKIKKMQARLDKVE
QLLQESPFPGASVWLEEIDAVEKAIIKGRNTQWKFH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8kgm Structure of African swine fever virus topoisomerase II in complex with dsDNA
Resolution4.8 Å
Binding residue
(original residue number in PDB)		V473 M475 N476 K547 S657 R660 R799 Y800 P852 S853 E854 G855 W856 K857 R1004 H1012
Binding residue
(residue number reindexed from 1)		V467 M469 N470 K541 S651 R654 R793 Y794 P846 S847 E848 G849 W850 K851 R998 H1006
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0000819 sister chromatid segregation
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8kgm, PDBe:8kgm, PDBj:8kgm
PDBsum8kgm
PubMed38816407
UniProtA0A2X0THW2

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