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Receptor Information

>8kd4 Chain B (length=542) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGSN
KELFTWFKNFVGYQCEAFGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWV
GHPVWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLET
IVNKIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDAL
HEHPAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGL
TFKQADKKLLTTKQLISEISSIKVDQTNKKIHWLTPKPKSQLDFDFPDKN
IFYDILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEESL
YSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINTRSTVTFAK
DLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWFEESLRQAY
NNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRNASTTSAKD
QIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIALDDLTL

>8kd4 Chain Y (length=164) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccctggagaatcccggtgccgaggccgctcaattggtcgtagacagctct
agcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaa
ggggattactccctagtctccaggcacgtgtcagatatatacatcctgtt
ctagagcggccgcc

Receptor-Ligand Complex Structure

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PDB	8kd4 Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Resolution	2.93 Å
Binding residue (original residue number in PDB)	E1220 H1221 Q1222 Q1247
Binding residue (residue number reindexed from 1)	E438 H439 Q440 Q465

Enzyme Commision number

	Molecular Function
GO:0003714	transcription corepressor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription

PDB	RCSB:8kd4, PDBe:8kd4, PDBj:8kd4
PDBsum	8kd4
PubMed	37666978
UniProt	P22579\|SIN3_YEAST Transcriptional regulatory protein SIN3 (Gene Name=SIN3)

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Structure of PDB 8kd4 Chain B Binding Site BS02