Structure of PDB 8jxh Chain B Binding Site BS02

Receptor Information

>8jxh Chain B (length=1166) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KEFECGSGECILRAYVCDHDNDCEDNSDERNCNYDTCGGHQFTCSNGQCI
NQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSGRCISIDKVC
DGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPGH
IINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCK
SSDSFSAASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKH
RVFWTDPMQEKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVET
KVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQP
KVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTY
DGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQ
VYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLG
YRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPV
TGSPSFFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESV
ECLTFDWISRNLYWTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPT
AGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSASRLYW
VDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAI
IRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNYCSQTTHANGDCSH
FCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNG
KCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWH
CDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDC
SDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCV
LNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHLDE
FQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCI
YKAWICDGDNDCRDMSDEKDCPTQPFHCPCSQKCENVVGSYICKCAPGYI
REPDGKSCRQNSNIEP

Ligand information

>8jxh Chain R (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ANAAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jxh Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution	3.5 Å
Binding residue (original residue number in PDB)	R828 W870 N872 H914 W930
Binding residue (residue number reindexed from 1)	R643 W685 N687 H729 W745

External links

PDB	RCSB:8jxh, PDBe:8jxh, PDBj:8jxh
PDBsum	8jxh
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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