Structure of PDB 8jxf Chain B Binding Site BS02

Receptor Information
>8jxf Chain B (length=1089) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTRPPGMCHLDEFQCQGDGTCIPNASHTCRSNEFQCLSPQRCIPSYWFCD
GEADCADGSDEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDM
SDEDQRHHCELQNCSSTQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDE
LQNCTMRTCSAGEFSCANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHA
NQFTCQNGRCIPRFFVCDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDN
GHCIEMGRVCNHVDDCSDNSDEKGCGINECLDSSISRCDHNCTDTITSFY
CSCLPGYKLMSDKRSCVDIDECKESPQLCSQKCENVVGSYICKCAPGYIR
EPDGKSCRQNSNIEPYLIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDF
DRVEKRLYWIDAEKQIIERMFLNKTNRETIINHRLRRAESLAVDWVSRKL
YWLDAILDCLFVSDLEGRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGH
VYWADWGVHAYIGRIGMDGTNKSVIISTKIEWPNAITIDYTNDLLYWADA
HLGYIEFSDLEGHHRHTVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGN
KYDGSGRVVLVNTTHKPFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKA
GGRGFTCACPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDG
QKDCSDGSDEPDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDE
DRVLCEHHRCESNEWQCANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRT
CRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEF
SCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIP
LRWKCDGTDDCGDNSDEENCVPRECSESEFRCADQQCIPSRWVCDQENDC
GDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPT
RFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCE
SPQRFRCDNSRCVYGHQLCNGVDDCGDGSDEKEEHCRKP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8jxf Chain B Residue 4707 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jxf Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		W2883 D2886 E2888 D2896 E2897
Binding residue
(residue number reindexed from 1)		W47 D50 E52 D60 E61
Annotation score4
External links
PDB RCSB:8jxf, PDBe:8jxf, PDBj:8jxf
PDBsum8jxf
PubMed38771880
UniProtP98158|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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