Structure of PDB 8jmh Chain B Binding Site BS02

Receptor Information
>8jmh Chain B (length=407) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LPNYTNLDLFHRAVFPFMFLAQCVAIMPLVGIRESNPRRVRFAYKSIPMF
VTLIFMIATSILFLSMFTHLLKIGITAKNFVGLVFFGCVLSAYVVFIRLA
KKWPAVVRIWTRTEIPFTKPPYEIPKRNLSRRVQLAALAIIGLSLGEHAL
YQVSAILSYTRRIQMCANITTVPSFNNYMQTNYDYVFQLLPYSPIIAVLI
LLINGACTFVWNYMDLFIMMISKGLSYRFEQITTRIRKLEHEEVCESVFI
QIREHYVKMCELLEFVDSAMSSLILLSCVNNLYFVCYQLLNVFNKLRWPI
NYIYFWYSLLYLIGRTAFVFLTAADINEESKRGLGVLRRVSSRSWCVEVE
RLIFQMTTQTVALSGKKFYFLTRRLLFGMAGTIVTYELVLLQFDEPNRRK
GLQPLCA
Ligand information
Ligand IDFRU
InChIInChI=1S/C6H12O6/c7-1-3-4(9)5(10)6(11,2-8)12-3/h3-5,7-11H,1-2H2/t3-,4-,5+,6-/m1/s1
InChIKeyRFSUNEUAIZKAJO-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OC1C(O)C(OC1(O)CO)CO
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)O
CACTVS 3.341OC[CH]1O[C](O)(CO)[CH](O)[CH]1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)O
CACTVS 3.341OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O
FormulaC6 H12 O6
Namebeta-D-fructofuranose;
beta-D-fructose;
D-fructose;
fructose
ChEMBLCHEMBL604608
DrugBank
ZINCZINC000001529270
PDB chain8jmh Chain F Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8jmh Structural basis for sugar perception by Drosophila gustatory receptors.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G131 F134 F135 Y200 Y234 N253
Binding residue
(residue number reindexed from 1)		G82 F85 F86 Y151 Y185 N204
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008527 taste receptor activity
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0033041 sweet taste receptor activity
GO:0170023 ionotropic sweet taste receptor activity
Biological Process
GO:0001582 detection of chemical stimulus involved in sensory perception of sweet taste
GO:0007165 signal transduction
GO:0007637 proboscis extension reflex
GO:0034220 monoatomic ion transmembrane transport
GO:0050909 sensory perception of taste
GO:0050912 detection of chemical stimulus involved in sensory perception of taste
GO:0050916 sensory perception of sweet taste
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jmh, PDBe:8jmh, PDBj:8jmh
PDBsum8jmh
PubMed38305684
UniProtP83293|GR64A_DROME Gustatory receptor for sugar taste 64a (Gene Name=Gr64a)

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