Structure of PDB 8jh4 Chain B Binding Site BS02

Receptor Information
>8jh4 Chain B (length=1161) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDTITTEDCWTVISAFFEEKGLVSQQLDSFDEFMETSIQDLVWEEPRLIL
DQPAQHTNEKDNINKRYEIRFGKIYLSRPTMTEADGTTHAMFPQEARLRN
LTYSSPVYLDMEKSMFTSIDGNKVHIGKVPIMLRSKFCSLRTLDEVDLYK
MKECPYDMGGYFVINGSEKVLIAQERSAANIVQVFKKAAPSPISHVAEIR
SALEKGSRLISTMQIKLYGREDKGTGRTIKATLPYVKQDIPIVIVFRALG
VVPDGEILQHICYDENDWQMLEMLKPCIEEGFVIQDKEVALDFIGRRGSA
ALGIRREKRIQYAKDILQKELLPHITQEEGFETRKTFFLGYMVNRLLLCA
LERKDQDDRDHFGKKRLDLAGPLLANLFRILFRKLTREIYRYMQRCIETD
RDFNLNLAVKSTTITSGLKYSLATGNWGEQKKAMSSRAGVSQVLNRYTYS
STLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNL
SLLSGISIGSPSEPIINFLEEWGMEPLEDYDPAQHTKSTRIFVNGVWTGI
HRDPSMLVSTMRDLRRSGAISPEVSIIRDIREREFKIFTDVGRVYRPLFI
VEDDESKDNKGELRITKEHIRKIQQGYDDDVYGWSSLVTSGVIEYVDGEE
EETIMIAMTPEDLQTRSLNDTAKRIKPEMSTSSHHTFTHCEIHPSMILGV
AASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNYNVRMDTMANILYYPQK
PLAKTQAMEYLKFRELPAGQNAIVAIACYSGYNQEDSMIMNQSSIDRGLF
RSLFFRSYMDQEKRFGISIVEEFEKPTRATTLRLKHGTYEKLDEDGLIAP
GVRVSGDDIIIGKTTPIPPYHTKRDASTPLRSTENGIVDQVLLTTNQEGL
KFVKVRMRTTKVPQIGDKFASRHGQKGTIGVTYRHEDMPFSAEGIVPDLI
INPHAIPSRMTVAHLIECLLSKVGSIRGYEGDATPFTDLTVDAVSNLLRD
NGYQSRGFEVMYNGHTGKKLMAQVFFGPTYYQRLRHMVDDKIHARARGPV
QVLTRQPVEGRSRDGGLRFGEMERDCMIAHGAAGFLKERLMEASDAFRVH
VCGICGLMSVIANLKKNQFECRSCKNKTNIYQLHIPYAAKLLFQELMAMN
IAPRLYTERSG
Ligand information
>8jh4 Chain T (length=178) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
atcagaatcccggtgccgaggccgctcaattggtcgtagacagctctagc
accgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgccaaggg
gattacacccaagacaccaggcacgagacagaaaaaaacaacgaaaacgg
ccaccacccaaacacaccaaacacaaga
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8jh4 Cryo-EM structures of RNA polymerase II-nucleosome complexes rewrapping transcribed DNA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R423 V475 R857 R1122 R1129
Binding residue
(residue number reindexed from 1)		R391 V443 R806 R1061 R1068
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0140727 siRNA-mediated pericentric heterochromatin formation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005721 pericentric heterochromatin

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8jh4, PDBe:8jh4, PDBj:8jh4
PDBsum8jh4
PubMed37981206
UniProtC4QZQ7

[Back to BioLiP]