Structure of PDB 8hr0 Chain B Binding Site BS02

Receptor Information
>8hr0 Chain B (length=729) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQ
TQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFL
DQRRWKCNLCYRVNDVPEEEPHRRPEVQNATIEFMAPSEYMLRPPQPPVY
LFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFY
GLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMF
TKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPN
HRSSAKMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYS
AGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSI
HTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLY
TSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTAS
LSDARDALVNAVIDSLSAYRSSVPGLMVPFSLRLFPLFVLALLKQKSFQT
GTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRT
IPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNY
ASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKAN
FLQNMIEDRTESALSYYEFLLHIQQQVNK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8hr0 Chain B Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8hr0 Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations
Resolution3.34 Å
Binding residue
(original residue number in PDB)		C431 C452 C455
Binding residue
(residue number reindexed from 1)		C86 C107 C110
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Cellular Component
GO:0030127 COPII vesicle coat

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8hr0, PDBe:8hr0, PDBj:8hr0
PDBsum8hr0
PubMed
UniProtO95486|SC24A_HUMAN Protein transport protein Sec24A (Gene Name=SEC24A)

[Back to BioLiP]