Structure of PDB 8hmz Chain B Binding Site BS02

Receptor Information
>8hmz Chain B (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLVVEVANGRSLVWGAEAVQALRERLGVGGRTVGALPRGPRQNSRLGLPL
LLMPEEARLLAEIGAVTLVSAPRPDSRHHSLALTSFKRQQEESFQEQSAL
AAEARETRRQELLEKITEGQAAKKQKLEQASGASPRSALLVQLATARPRP
VKARPLDWRVQSKDWPHAGRPAHELRYSIYRDLWERGFFLSAAGKFGGDF
LVYPGDPLRFHAHYIAQCWAPEDTIPLQDLVAAGRLGTSVRKTLLLCSPQ
PDGKVVYTSLQWAS
Ligand information
>8hmz Chain 3 (length=37) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auucaaagguuguggguucgaaucccaccagagucgg
...........<<<<<.......>>>>>.........
Receptor-Ligand Complex Structure
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PDB8hmz Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		I116 Q120 K123 K286
Binding residue
(residue number reindexed from 1)		I116 Q120 K123 K242
Enzymatic activity
Enzyme Commision number 4.6.1.16: tRNA-intron lyase.
Gene Ontology
Molecular Function
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0016829 lyase activity
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus

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Biological Process
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Cellular Component
External links
PDB RCSB:8hmz, PDBe:8hmz, PDBj:8hmz
PDBsum8hmz
PubMed37028420
UniProtQ9BSV6|SEN34_HUMAN tRNA-splicing endonuclease subunit Sen34 (Gene Name=TSEN34)

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