Structure of PDB 8h0i Chain B Binding Site BS02

Receptor Information
>8h0i Chain B (length=345) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPGHMDPDTFSYNFNNRPILSRRNTVWLCYEVERLDNGTWVKMDQHRGQV
YSELKYHPEMRFLSLVSKWKLHRDQEYEVTWYISWSPCTKCARDMATFLQ
ENTHVTLTIFVARLYYFWDPDYQEALRSLAQAGATIKIMNYDEFQHCWSK
FVYSQGAPFQPWDGLDEYSQALSGMLGEILRHSMDPPTFTFNFNNERHET
YLCYEVERMHNDTWVKLNQRRGFLANQRHAELCFLDVIPFWKLDLDQDYR
VTCFTSWSPCFSCAQEMAKFISKNKHVSLCIKTARIYQEGLRTLAEAGAK
ISIMTYSEFKHCWDTFVDHQGAPFQPWDGLDEHSQDLSGRLRAIL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8h0i Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8h0i Structural insights into RNA bridging between HIV-1 Vif and antiviral factor APOBEC3G.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H53 C84 C87
Binding residue
(residue number reindexed from 1)		H57 C88 C91
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8h0i, PDBe:8h0i, PDBj:8h0i
PDBsum8h0i
PubMed37419875
UniProtQ9HC16|ABC3G_HUMAN DNA dC->dU-editing enzyme APOBEC-3G (Gene Name=APOBEC3G)

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