Structure of PDB 8fok Chain B Binding Site BS02

Receptor Information
>8fok Chain B (length=430) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSSEEEKKLYARLYESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIES
CLSRNKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRS
KELREKFVRAETFLFKIRFNMLTSTDQTKFVQSLQFISNEEKAELSHQLY
QTVSASLQFQLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDG
YAYLQQLNLLSNEFASKLNQELIKTYQYLPRLNEDDRLLPILNHLSSGYT
DEINAQSVWSEEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIG
LSADEALKFWSEAFTTMEKFNKEYRYSFRHNYGLEGNRINYKPWDCHTIL
SKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYT
IACTKVFEMTHQTHIAHPNLYFERSRQLQK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8fok Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8fok Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Resolution3.56 Å
Binding residue
(original residue number in PDB)		C336 C417 I420 C434 F436 Y470 C474 P500
Binding residue
(residue number reindexed from 1)		C270 C346 I349 C363 F365 Y399 C403 P418
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fok, PDBe:8fok, PDBj:8fok
PDBsum8fok
PubMed37344454
UniProtP20457|PRI2_YEAST DNA primase large subunit (Gene Name=PRI2)

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