Structure of PDB 8foh Chain B Binding Site BS02

Receptor Information
>8foh Chain B (length=406) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEKKLYARLYESKLSFYDLPPQEQFEIWAIDRLKILLEIESCLSRNKSIK
EIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRSKELREKFVR
AETFLFKIRFNMLTSTDQTKFVQSLQFISNEEKAELSHQLYQTVSASLQF
QLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDGYAYLQQLNL
LSNEFASKLNQELIKTYQYLPRLNEDRLLPILNHLSSGYTDEINAQSVWS
EEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIGLSADEALKFW
SEAFTKEYRYSFRHNYGLEGNRINYKPWDCHTILSKPRPGRGDYHGCPFR
DWSHERLSAELRAQIISVLDSCQKGEYTIACTKVFEMTHHIAHPNLYFER
SRQLQK
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain8foh Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8foh Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Resolution4.6 Å
Binding residue
(original residue number in PDB)		P334 C336 C417 I420 C434 F436 T471 C474 P500
Binding residue
(residue number reindexed from 1)		P258 C260 C330 I333 C347 F349 T378 C381 P394
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005658 alpha DNA polymerase:primase complex
GO:1990077 primosome complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8foh, PDBe:8foh, PDBj:8foh
PDBsum8foh
PubMed37344454
UniProtP20457|PRI2_YEAST DNA primase large subunit (Gene Name=PRI2)

[Back to BioLiP]