Structure of PDB 8fh3 Chain B Binding Site BS02

Receptor Information
>8fh3 Chain B (length=1152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRAVLTWRDKAEHCINDIAFKPDGTQLILAAGSRLLVYDTSDGTLLQPLK
GHKDTVYCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDAIQCVS
YNPITHQLASCSSSDFGLWSPEQKSVSKHKSSSKIICCSWTNDGQYLALG
MFNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPSSRWESFWMNREIQ
EIPSTLKNLEERNDILAVADWGQKVSFYQLSGKQIGKDRALNFDPCCISY
FTKGEYILLGGSDKQVSLFTKDGVRLGTVGEQNSWVWTCQAKPDSNYVVV
GCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQKVRIKCK
ELVKKIAIYRNRLAIQLPEKILIYELYSEDLSDMHYRVKEKIIKKFECNL
LVVCANHIILCQEKRLQCLSFSGVKEREWQMESLIRYIKVIGGPPGREGL
LVGLKNGQILKIFVDNLFAIVLLKQATAVRCLDMSASRKKLAVVDENDTC
LVYDIDTKELLFQEPNANSVAWNTQCEDMLCFSGGGYLNIKASTFPVHRQ
KLQGFVVGYNGSKIFCLHVFSISAVEVPQSAPMYQYLDRKLFKEAYQIAC
LGVTDTDWRELAMEALEGLDFETAKKAFIRVQDLRYLELISSIEERKKRG
ETNNDLFLADVFSYQGKFHEAAKLYKRSGHENLALEMYTDLCMFEYAKDF
LGSGDPKETKMLITKQADWARNIKEPKAAVEMYISAGEHVKAIEICGDHG
WVDMLIDIARKLDKAEREPLLLCATYLKKLDSPGYAAETYLKMGDLKSLV
QLHVETQRWDEAFALGEKHPEFKDDIYMPYAQWLAENDRFEEAQKAFHKA
GRQREAVQVLEQLTNNAVAESRFNDAAYYYWMLSMQCLDIAQDPAQKDTM
LGKFYHFQRLAELYHGYHAIHRHTEDPFSVHRPETLFNISRFLLHSLPKD
TPSGISKVKILFTLAKQSKALGAYRLARHAYDKLRGLYIPARFQKSIELG
TLTIRAKPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSASSY
DVLHLVEFYLEEGITDEEAISLIDLESEFVPVVVSRLVLRSMSRRDVLIK
RWPPPLRWQYFRSLLPDASITMCPSCFQMFHSEDYELLVLQHGCCPYCRR
CK
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8fh3 Chain B Residue 1302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fh3 Human IFT-A complex structures provide molecular insights into ciliary transport.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		C1207 C1229 C1232
Binding residue
(residue number reindexed from 1)		C1123 C1145 C1148
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001843 neural tube closure
GO:0010172 embryonic body morphogenesis
GO:0021513 spinal cord dorsal/ventral patterning
GO:0030030 cell projection organization
GO:0035050 embryonic heart tube development
GO:0035115 embryonic forelimb morphogenesis
GO:0035556 intracellular signal transduction
GO:0035720 intraciliary anterograde transport
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048593 camera-type eye morphogenesis
GO:0060173 limb development
GO:0060271 cilium assembly
GO:0060971 embryonic heart tube left/right pattern formation
GO:0061512 protein localization to cilium
GO:0072594 establishment of protein localization to organelle
GO:1905515 non-motile cilium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0016020 membrane
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0097542 ciliary tip
GO:0097730 non-motile cilium

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fh3, PDBe:8fh3, PDBj:8fh3
PDBsum8fh3
PubMed36775821
UniProtQ9HBG6|IF122_HUMAN Intraflagellar transport protein 122 homolog (Gene Name=IFT122)

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