Structure of PDB 8ezh Chain B Binding Site BS02

Receptor Information
>8ezh Chain B (length=416) Species: 220668 (Lactiplantibacillus plantarum WCFS1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVAIDLPYDKRTITAQIDDENYAGKLVSQAATYHNKLSEQETVEKSLDNP
IGSDKLEELARGKHNIVIISSDHTRPVPSHIITPILLRRLRSVAPDAAIA
ILVATGFHRPSTHEELVNKYGEDIVNNEEIVMHVSTDDSSMVKIGQLPSG
GDCIINKVAAEADLLISEGFIESHFFAGFSGGRKSVLPGIASYKTIMANH
SGEFARTGNLMHNSIHKDMVYAARTAKLAFIINVVLDEDKKIIGSFAGDM
EAAHKVGCDFVKELSSVPAIDCDIAISTNGGYPLDQNIYQAVKGMTAAEA
TNKEGGTIIMVAGARDGHGGEGFYHNLADVDDPKEFLDQIPDQWTAQIFA
RILVHHHVIFVSDLVDPDLITNMHMELAKTLDEAMEKAYAREGQAAKVTV
IPDGLGVIVKASWSHP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8ezh Chain B Residue 508 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ezh Irreversible Inactivation of Lactate Racemase by Sodium Borohydride Reveals Reactivity of the Nickel-Pincer Nucleotide Cofactor
Resolution1.99 Å
Binding residue
(original residue number in PDB)		D396 E400
Binding residue
(residue number reindexed from 1)		D382 E386
Annotation score1
Enzymatic activity
Enzyme Commision number 5.1.2.1: lactate racemase.
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0046872 metal ion binding
GO:0050043 lactate racemase activity

View graph for
Molecular Function
External links
PDB RCSB:8ezh, PDBe:8ezh, PDBj:8ezh
PDBsum8ezh
PubMed37886035
UniProtF9USS9|LARA_LACPL Lactate racemase (Gene Name=larA)

[Back to BioLiP]