Structure of PDB 8epk Chain B Binding Site BS02

Receptor Information
>8epk Chain B (length=235) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKIT
VVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLV
LNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPL
VDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDAGGPHVTEVEGTSFLT
GIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Ligand information
>8epk Chain F (length=31) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guggacuauaccgcguaaugcugccuccacu
<<<<<.......<<.....>>....>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8epk An RNA aptamer exploits exosite-dependent allostery to achieve specific inhibition of coagulation factor IXa.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		F145 K148
Binding residue
(residue number reindexed from 1)		F134 K136
External links
PDB RCSB:8epk, PDBe:8epk, PDBj:8epk
PDBsum8epk
PubMed38985762
UniProtP00740|FA9_HUMAN Coagulation factor IX (Gene Name=F9)

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