Structure of PDB 8cxw Chain B Binding Site BS02

Receptor Information
>8cxw Chain B (length=549) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILYD
LFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSLT
NKKVVNDLDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKY
KKFLLEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSG
KDLREYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVF
KIKNEDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYN
KIQEKCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIK
SKNINKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECK
SGIRKWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSF
FIKEEYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKI
RIFRDNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Receptor-Ligand Complex Structure
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PDB8cxw Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.78 Å
Binding residue
(original residue number in PDB)		H171 K172 K176 K179 D192 K193 I349 G351 D353 K378 K380 R425 Q438 W439 Y455 K456 K515
Binding residue
(residue number reindexed from 1)		H143 K144 K148 K151 D164 K165 I321 G323 D325 K350 K352 R397 Q410 W411 Y427 K428 K487
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxw, PDBe:8cxw, PDBj:8cxw
PDBsum8cxw
PubMed36581322
UniProtQ183J3

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